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    Mboat7 membrane bound O-acyltransferase domain containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 77582, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mboat7provided by MGI
    Official Full Name
    membrane bound O-acyltransferase domain containing 7provided by MGI
    Primary source
    MGI:MGI:1924832
    See related
    Ensembl:ENSMUSG00000035596 AllianceGenome:MGI:1924832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BB1; Leng4; Lpiat; Lpiat1; LPLAT 7; m-mboa-7; 5730589L02Rik
    Summary
    Enables O-acyltransferase activity and lysophospholipid acyltransferase activity. Involved in phosphatidylinositol acyl-chain remodeling and regulation of triglyceride metabolic process. Acts upstream of or within layer formation in cerebral cortex; phosphatidylinositol metabolic process; and ventricular system development. Located in membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 41.2), ovary adult (RPKM 26.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mboat7 in Genome Data Viewer
    Location:
    7 A1; 7 2.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3680788..3696188, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3677789..3693189, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex, subunit 3 Neighboring gene microRNA 3572 Neighboring gene STARR-positive B cell enhancer ABC_E1077 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene STARR-positive B cell enhancer ABC_E2812 Neighboring gene ribosomal protein S9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables lysophospholipid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lysophospholipid acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within layer formation in cerebral cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine acyl-chain remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol acyl-chain remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol acyl-chain remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within phosphatidylinositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of triglyceride metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    lysophospholipid acyltransferase 7
    Names
    1-acylglycerophosphatidylinositol O-acyltransferase
    bladder and breast carcinoma-overexpressed gene 1 protein
    leukocyte receptor cluster (LRC) member 4
    lysophosphatidylinositol acyltransferase 1
    membrane-bound O-acyltransferase domain-containing protein 7
    NP_084210.2
    XP_006540495.1
    XP_006540496.1
    XP_011249044.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029934.4NP_084210.2  lysophospholipid acyltransferase 7

      Status: VALIDATED

      Source sequence(s)
      AC171680
      Consensus CDS
      CCDS20724.1
      UniProtKB/Swiss-Prot
      Q3UDM6, Q8CHK3, Q8R1P9, Q9CY76
      Related
      ENSMUSP00000037107.8, ENSMUST00000038608.14
      Conserved Domains (1) summary
      cl00738
      Location:8431
      MBOAT; membrane-bound O-acyltransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3680788..3696188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540433.4XP_006540496.1  lysophospholipid acyltransferase 7 isoform X2

      Conserved Domains (1) summary
      cl00738
      Location:117408
      MBOAT; membrane-bound O-acyltransferase family
    2. XM_006540432.5XP_006540495.1  lysophospholipid acyltransferase 7 isoform X1

      UniProtKB/Swiss-Prot
      Q3UDM6, Q8CHK3, Q8R1P9, Q9CY76
      Conserved Domains (1) summary
      cl00738
      Location:8431
      MBOAT; membrane-bound O-acyltransferase family
    3. XM_011250742.3XP_011249044.1  lysophospholipid acyltransferase 7 isoform X2

      Conserved Domains (1) summary
      cl00738
      Location:117408
      MBOAT; membrane-bound O-acyltransferase family