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    Tbcc tubulin-specific chaperone C [ Mus musculus (house mouse) ]

    Gene ID: 72726, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tbccprovided by MGI
    Official Full Name
    tubulin-specific chaperone Cprovided by MGI
    Primary source
    MGI:MGI:1919976
    See related
    Ensembl:ENSMUSG00000036430 AllianceGenome:MGI:1919976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810055C19Rik
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in post-chaperonin tubulin folding pathway and tubulin complex assembly. Predicted to be located in cytosol and photoreceptor connecting cilium. Predicted to be active in cytoplasm. Is expressed in Meckel's cartilage; autopod; and skeleton. Orthologous to human TBCC (tubulin folding cofactor C). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See Tbcc in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47201547..47203389)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46890621..46892463)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7539 Neighboring gene STARR-positive B cell enhancer ABC_E7540 Neighboring gene STARR-seq mESC enhancer starr_42679 Neighboring gene ribosomal protein L7-like 1 Neighboring gene STARR-seq mESC enhancer starr_42682 Neighboring gene BRD4 interacting chromatin remodeling complex associated protein like Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:46965989-46966172 Neighboring gene STARR-seq mESC enhancer starr_42687 Neighboring gene STARR-seq mESC enhancer starr_42689 Neighboring gene STARR-positive B cell enhancer ABC_E170 Neighboring gene STARR-seq mESC enhancer starr_42692 Neighboring gene peripherin 2 Neighboring gene ubiquitin protein ligase E3 component n-recognin 2 Neighboring gene STARR-positive B cell enhancer ABC_E3205

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy. Wen HL, et al. Hum Mol Genet, 2010 May 1. PMID 20176735
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC103238

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in post-chaperonin tubulin folding pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-chaperonin tubulin folding pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor connecting cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tubulin-specific chaperone C
    Names
    CFC
    tubulin-folding cofactor C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178385.3 → NP_848472.2  tubulin-specific chaperone C

      See identical proteins and their annotated locations for NP_848472.2

      Status: VALIDATED

      Source sequence(s)
      AK132036, BY299869
      Consensus CDS
      CCDS28843.1
      UniProtKB/Swiss-Prot
      Q3V242, Q8VCN9
      UniProtKB/TrEMBL
      A0A0R4J0M1
      Related
      ENSMUSP00000048696.8, ENSMUST00000040434.9
      Conserved Domains (2) summary
      pfam07986
      Location:199 → 316
      TBCC; Tubulin binding cofactor C
      pfam16752
      Location:28 → 134
      TBCC_N; Tubulin-specific chaperone C N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47201547..47203389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCN9.1 GenPept UniProtKB/Swiss-Prot:Q8VCN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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