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    Zbtb14 zinc finger and BTB domain containing 14 [ Mus musculus (house mouse) ]

    Gene ID: 22666, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zbtb14provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 14provided by MGI
    Primary source
    MGI:MGI:1195345
    See related
    Ensembl:ENSMUSG00000049672 AllianceGenome:MGI:1195345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZF5; Zfp161; b2b1982Clo
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within heart development and kidney development. Predicted to be located in aggresome; cytosol; and nucleolus. Predicted to be active in nucleoplasm. Is expressed in central nervous system and ureter. Orthologous to human ZBTB14 (zinc finger and BTB domain containing 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.3), CNS E14 (RPKM 5.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zbtb14 in Genome Data Viewer
    Location:
    17 E1.3; 17 40.42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (69690170..69697747)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (69383175..69390752)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 3 Neighboring gene RIKEN cDNA 2410021H03 gene Neighboring gene STARR-seq mESC enhancer starr_43121 Neighboring gene STARR-seq mESC enhancer starr_43123 Neighboring gene STARR-seq mESC enhancer starr_43125 Neighboring gene predicted gene, 53973 Neighboring gene RIKEN cDNA C030034I22 gene Neighboring gene STARR-seq mESC enhancer starr_43127 Neighboring gene RIKEN cDNA A730049N16 gene Neighboring gene A kinase anchor inhibitor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in aggresome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 14
    Names
    zfp-161
    zinc finger protein 161
    zinc finger protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356282.1NP_001343211.1  zinc finger and BTB domain-containing protein 14

      Status: VALIDATED

      Source sequence(s)
      AC122487, AK082051, AK136762, AK145517, BC052017, BY070865
      Consensus CDS
      CCDS37682.1
      UniProtKB/Swiss-Prot
      Q08376
      UniProtKB/TrEMBL
      Q544H8
      Related
      ENSMUSP00000054897.8, ENSMUST00000062369.14
      Conserved Domains (4) summary
      COG5189
      Location:303383
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:307327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18204
      Location:18131
      BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
      pfam13465
      Location:319344
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001356283.1NP_001343212.1  zinc finger and BTB domain-containing protein 14

      Status: VALIDATED

      Source sequence(s)
      AC122487
      Consensus CDS
      CCDS37682.1
      UniProtKB/Swiss-Prot
      Q08376
      UniProtKB/TrEMBL
      Q544H8
      Related
      ENSMUSP00000108294.2, ENSMUST00000112674.8
      Conserved Domains (4) summary
      COG5189
      Location:303383
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:307327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18204
      Location:18131
      BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
      pfam13465
      Location:319344
      zf-H2C2_2; Zinc-finger double domain
    3. NM_009547.3NP_033573.1  zinc finger and BTB domain-containing protein 14

      See identical proteins and their annotated locations for NP_033573.1

      Status: VALIDATED

      Source sequence(s)
      AK082051, AK136762, BC052017, CB247149
      Consensus CDS
      CCDS37682.1
      UniProtKB/Swiss-Prot
      Q08376
      UniProtKB/TrEMBL
      Q544H8
      Related
      ENSMUSP00000108296.3, ENSMUST00000112676.4
      Conserved Domains (4) summary
      COG5189
      Location:303383
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:307327
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18204
      Location:18131
      BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
      pfam13465
      Location:319344
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      69690170..69697747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)