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    Eri1 exoribonuclease 1 [ Mus musculus (house mouse) ]

    Gene ID: 67276, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eri1provided by MGI
    Official Full Name
    exoribonuclease 1provided by MGI
    Primary source
    MGI:MGI:1914526
    See related
    Ensembl:ENSMUSG00000031527 AllianceGenome:MGI:1914526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Thex1; eri-1; 3'hexo; 3110010F15Rik
    Summary
    Enables histone pre-mRNA stem-loop binding activity; rRNA binding activity; and ribosome binding activity. Involved in rRNA 3'-end processing. Located in cytoplasm and nucleolus. Part of histone pre-mRNA 3'end processing complex. Is expressed in early conceptus; eye; inner cell mass; limb; and oocyte. Orthologous to human ERI1 (exoribonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 6.8), liver E14.5 (RPKM 5.6) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Eri1 in Genome Data Viewer
    Location:
    8 A4; 8 21.16 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (35932419..35962687, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (35465265..35495533, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34911 Neighboring gene predicted gene, 51567 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:36493910-36494093 Neighboring gene predicted gene, 34853 Neighboring gene STARR-positive B cell enhancer ABC_E9725 Neighboring gene predicted gene, 51568 Neighboring gene predicted gene, 39162

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone pre-mRNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of histone pre-mRNA 3'end processing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    3'-5' exoribonuclease 1
    Names
    3'-5' exonuclease ERI1
    enhanced RNAi protein 1
    eri-1 homolog
    histone mRNA 3' end-specific exonuclease
    histone mRNA 3'-exonuclease 1
    three prime histone mRNA exonuclease 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026067.3NP_080343.4  3'-5' exoribonuclease 1

      Status: VALIDATED

      Source sequence(s)
      AK014410, AK050230, AK161031, AK165026
      Consensus CDS
      CCDS22244.1
      UniProtKB/TrEMBL
      A0A0R4J0C8
      Related
      ENSMUSP00000033927.7, ENSMUST00000033927.8
      Conserved Domains (2) summary
      cd06133
      Location:126306
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
      pfam02037
      Location:72106
      SAP; SAP domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      35932419..35962687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154250.1XP_036010143.1  3'-5' exoribonuclease 1 isoform X1

      Conserved Domains (2) summary
      cd06133
      Location:60240
      ERI-1_3'hExo_like; DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins
      pfam02037
      Location:640
      SAP; SAP domain