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    Coq5 coenzyme Q5 methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 52064, updated on 9-Dec-2024

    Summary

    Official Symbol
    Coq5provided by MGI
    Official Full Name
    coenzyme Q5 methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1098643
    See related
    Ensembl:ENSMUSG00000041733 AllianceGenome:MGI:1098643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Ertd33e; 1810014G04Rik
    Summary
    Predicted to enable 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. Predicted to be involved in methylation and ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in heart and heart right ventricle. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 22.2), cerebellum adult (RPKM 9.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Coq5 in Genome Data Viewer
    Location:
    5 F; 5 56.03 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115417752..115435029)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115279666..115296974)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8072 Neighboring gene processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) Neighboring gene ring finger protein 10 Neighboring gene STARR-seq mESC enhancer starr_14112 Neighboring gene STARR-positive B cell enhancer ABC_E3605 Neighboring gene STARR-seq mESC enhancer starr_14114 Neighboring gene STARR-positive B cell enhancer ABC_E530 Neighboring gene dynein light chain LC8-type 1 Neighboring gene predicted gene 13830

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquinone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquinone biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquinone biosynthesis complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquinone biosynthesis complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
    Names
    coenzyme Q5 homolog, methyltransferase
    ubiquinone biosynthesis methyltransferase COQ5, mitochondrial
    NP_080780.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026504.3NP_080780.1  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080780.1

      Status: VALIDATED

      Source sequence(s)
      AC145070
      Consensus CDS
      CCDS19585.1
      UniProtKB/Swiss-Prot
      Q9CXI0, Q9D6Y6, Q9D900
      Related
      ENSMUSP00000048001.5, ENSMUST00000040421.11
      Conserved Domains (1) summary
      PRK00216
      Location:56327
      ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed

    RNA

    1. NR_184540.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC145070

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      115417752..115435029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)