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    Yod1 YOD1 deubiquitinase [ Mus musculus (house mouse) ]

    Gene ID: 226418, updated on 9-Dec-2024

    Summary

    Official Symbol
    Yod1provided by MGI
    Official Full Name
    YOD1 deubiquitinaseprovided by MGI
    Primary source
    MGI:MGI:2442596
    See related
    Ensembl:ENSMUSG00000046404 AllianceGenome:MGI:2442596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hshin7; 6330564D18Rik; 9930028C20Rik
    Summary
    Predicted to enable K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein deubiquitination. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.7), liver E14 (RPKM 3.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Yod1 in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130645064..130652093)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130717327..130722073)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene complement component 4 binding protein Neighboring gene STARR-seq mESC enhancer starr_02200 Neighboring gene complement component 4 binding protein, pseudogene 1 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Neighboring gene STARR-positive B cell enhancer ABC_E1230 Neighboring gene STARR-seq mESC enhancer starr_02204 Neighboring gene expressed sequence AA986860 Neighboring gene predicted gene 28857 Neighboring gene predicted gene 28856 Neighboring gene STARR-seq mESC enhancer starr_02205

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables K48-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macroautophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K27-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K27-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K29-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K29-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K33-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K33-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ubiquitin thioesterase OTU1
    Names
    HIV-induced protein-7-like protease
    YOD1 OTU deubiquitinating enzyme 1 homologue
    NP_848806.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178691.5NP_848806.2  ubiquitin thioesterase OTU1

      See identical proteins and their annotated locations for NP_848806.2

      Status: VALIDATED

      Source sequence(s)
      AC139231
      Consensus CDS
      CCDS48351.1
      UniProtKB/Swiss-Prot
      B2RSW9, Q8BPM9, Q8CB24, Q8CB27
      UniProtKB/TrEMBL
      A4FTZ0
      Related
      ENSMUSP00000055318.5, ENSMUST00000049813.6
      Conserved Domains (3) summary
      COG5539
      Location:72342
      COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
      cl00155
      Location:4184
      UBQ; Ubiquitin-like proteins
      cl19932
      Location:150265
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130645064..130652093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)