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    Tnfaip8l2 tumor necrosis factor, alpha-induced protein 8-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 69769, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnfaip8l2provided by MGI
    Official Full Name
    tumor necrosis factor, alpha-induced protein 8-like 2provided by MGI
    Primary source
    MGI:MGI:1917019
    See related
    Ensembl:ENSMUSG00000013707 AllianceGenome:MGI:1917019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TIPE2; 1810019A08Rik
    Summary
    Acts upstream of or within negative regulation of T cell activation and negative regulation of inflammatory response. Located in cytoplasm. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human TNFAIP8L2 (TNF alpha induced protein 8 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 43.4), thymus adult (RPKM 22.0) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnfaip8l2 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95046832..95051581, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95139521..95142416, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94937828-94938011 Neighboring gene sodium channel modifier 1 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 1 Neighboring gene microRNA 8099-1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94945477-94945712 Neighboring gene predicted gene 9169 Neighboring gene STARR-seq mESC enhancer starr_08369 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor alpha-induced protein 8-like protein 2
    Names
    TNF alpha-induced protein 8-like protein 2
    TNFAIP8-like protein 2
    tumor necrosis factor, alpha-induced protein 8-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027206.3NP_081482.1  tumor necrosis factor alpha-induced protein 8-like protein 2

      See identical proteins and their annotated locations for NP_081482.1

      Status: VALIDATED

      Source sequence(s)
      AC131769
      Consensus CDS
      CCDS17603.1
      UniProtKB/Swiss-Prot
      Q9D8Y7
      Related
      ENSMUSP00000013851.4, ENSMUST00000013851.4
      Conserved Domains (1) summary
      pfam05527
      Location:25177
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95046832..95051581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502040.5XP_006502103.1  tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006502103.1

      UniProtKB/Swiss-Prot
      Q9D8Y7
      Conserved Domains (1) summary
      pfam05527
      Location:25177
      DUF758; Domain of unknown function (DUF758)