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    Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 56050, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cyp39a1provided by MGI
    Official Full Name
    cytochrome P450, family 39, subfamily a, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1927096
    See related
    Ensembl:ENSMUSG00000023963 AllianceGenome:MGI:1927096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mCYP39A1
    Summary
    Enables oxysterol 7-alpha-hydroxylase activity and steroid 7-alpha-hydroxylase activity. Involved in bile acid biosynthetic process. Acts upstream of or within cholesterol catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human CYP39A1 (cytochrome P450 family 39 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 16.7), bladder adult (RPKM 3.0) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cyp39a1 in Genome Data Viewer
    Location:
    17 B3; 17 19.75 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43978263..44062322)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43667372..43751431)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:43782177-43782395 Neighboring gene tudor domain containing 6 Neighboring gene solute carrier family 25, member 27 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43837943-43838243 Neighboring gene STARR-seq mESC enhancer starr_42600 Neighboring gene STARR-seq mESC enhancer starr_42601 Neighboring gene predicted gene, 25783 Neighboring gene predicted gene, 41581 Neighboring gene predicted gene, 34773 Neighboring gene regulator of calcineurin 2 Neighboring gene STARR-seq mESC enhancer starr_42606 Neighboring gene STARR-seq mESC enhancer starr_42607

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 24-hydroxycholesterol 7alpha-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxysterol 7-alpha-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxysterol 7-alpha-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxysterol 7-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid 7-alpha-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables steroid 7-alpha-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bile acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bile acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in digestion TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    24-hydroxycholesterol 7-alpha-hydroxylase
    Names
    cytochrome P450, 39a1 (oxysterol 7alpha-hydroxylase)
    oxysterol 7-alpha-hydroxylase
    NP_001272876.1
    NP_001272877.1
    NP_061375.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285947.2NP_001272876.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform 2

      See identical proteins and their annotated locations for NP_001272876.1

      Status: VALIDATED

      Source sequence(s)
      AC154204, AC154647
      Consensus CDS
      CCDS89101.1
      UniProtKB/TrEMBL
      A0A3B2WCK5, Q8CFY8
      Related
      ENSMUSP00000156567.2, ENSMUST00000233437.2
      Conserved Domains (1) summary
      cl12078
      Location:32409
      p450; Cytochrome P450
    2. NM_001285948.2NP_001272877.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154204, AC154647
      Consensus CDS
      CCDS89100.1
      UniProtKB/TrEMBL
      A0A3B2W4C8, Q05CS3
      Related
      ENSMUSP00000156870.2, ENSMUST00000233627.2
      Conserved Domains (1) summary
      cl12078
      Location:32388
      p450; Cytochrome P450
    3. NM_018887.5NP_061375.1  24-hydroxycholesterol 7-alpha-hydroxylase isoform 1

      See identical proteins and their annotated locations for NP_061375.1

      Status: VALIDATED

      Source sequence(s)
      AC154204, AC154647
      Consensus CDS
      CCDS28799.1
      UniProtKB/Swiss-Prot
      Q9JKJ9
      UniProtKB/TrEMBL
      Q544S6, Q8CFY8
      Related
      ENSMUSP00000130073.2, ENSMUST00000170988.2
      Conserved Domains (1) summary
      cl12078
      Location:32459
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43978263..44062322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)