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    Get1 guided entry of tail-anchored proteins factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 71446, updated on 9-Dec-2024

    Summary

    Official Symbol
    Get1provided by MGI
    Official Full Name
    guided entry of tail-anchored proteins factor 1provided by MGI
    Primary source
    MGI:MGI:2136882
    See related
    Ensembl:ENSMUSG00000023147 AllianceGenome:MGI:2136882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wrb; Chd5; 5530402J05Rik; C030018G21Rik
    Summary
    Predicted to enable protein-membrane adaptor activity. Acts upstream of or within several processes, including otic vesicle development; post-translational protein targeting to endoplasmic reticulum membrane; and sensory perception of sound. Predicted to be located in endoplasmic reticulum. Predicted to be part of GET complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skeleton. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 29.6), whole brain E14.5 (RPKM 25.0) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Get1 in Genome Data Viewer
    Location:
    16 C4; 16 56.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (95946600..95959052)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (96145400..96157852)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41611 Neighboring gene bromodomain and WD repeat domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_41612 Neighboring gene STARR-seq mESC enhancer starr_41614 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:96307304-96307505 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96331382-96331682 Neighboring gene STARR-positive B cell enhancer mm9_chr16:96349246-96349547 Neighboring gene high mobility group nucleosomal binding domain 1 Neighboring gene Leber congenital amaurosis 5-like Neighboring gene STARR-positive B cell enhancer ABC_E7483 Neighboring gene predicted gene, 53923 Neighboring gene SH3-binding domain glutamic acid-rich protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC98437

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within otic vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within startle response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tail-anchored membrane protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tail-anchored membrane protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of GET complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of GET complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of GET complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    guided entry of tail-anchored proteins factor 1
    Names
    tail-anchored protein insertion receptor WRB
    tryptophan rich basic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207301.3NP_997184.1  guided entry of tail-anchored proteins factor 1

      See identical proteins and their annotated locations for NP_997184.1

      Status: VALIDATED

      Source sequence(s)
      AC164647
      Consensus CDS
      CCDS28354.1
      UniProtKB/Swiss-Prot
      Q3TA55, Q8K0D7, Q9D1W0
      Related
      ENSMUSP00000023913.9, ENSMUST00000023913.11
      Conserved Domains (1) summary
      pfam04420
      Location:17163
      CHD5; CHD5-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      95946600..95959052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)