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    Lrrc28 leucine rich repeat containing 28 [ Mus musculus (house mouse) ]

    Gene ID: 67867, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrrc28provided by MGI
    Official Full Name
    leucine rich repeat containing 28provided by MGI
    Primary source
    MGI:MGI:1915689
    See related
    Ensembl:ENSMUSG00000030556 AllianceGenome:MGI:1915689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300004K21Rik; 2210012C09Rik; 2310058O11Rik
    Summary
    Orthologous to human LRRC28 (leucine rich repeat containing 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 53.0), bladder adult (RPKM 4.5) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lrrc28 in Genome Data Viewer
    Location:
    7 C; 7 37.05 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (67163158..67295084, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (67513410..67645336, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:74565953-74566106 Neighboring gene STARR-positive B cell enhancer ABC_E3726 Neighboring gene predicted gene, 51462 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:74589405-74589631 Neighboring gene STARR-positive B cell enhancer ABC_E4934 Neighboring gene predicted gene, 33926 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:74645213-74645604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:74648142-74648407 Neighboring gene predicted gene, 34079 Neighboring gene predicted gene, 23233 Neighboring gene STARR-seq mESC enhancer starr_19098 Neighboring gene predicted gene, 32983 Neighboring gene STARR-seq mESC enhancer starr_19100 Neighboring gene STARR-seq mESC enhancer starr_19102 Neighboring gene STARR-positive B cell enhancer ABC_E550 Neighboring gene tetratricopeptide repeat domain 23 Neighboring gene predicted gene, 34140 Neighboring gene synemin, intermediate filament protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 28

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027413.1NP_081689.1  leucine-rich repeat-containing protein 28 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AI663251, AK008713, AK050154
      Consensus CDS
      CCDS52269.1
      UniProtKB/TrEMBL
      Q8BWS3, Q9D7Y1
      Related
      ENSMUSP00000032775.6, ENSMUST00000032775.12
      Conserved Domains (2) summary
      sd00033
      Location:2042
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65123
      LRR_8; Leucine rich repeat
    2. NM_175124.5NP_780333.3  leucine-rich repeat-containing protein 28 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI663251, BC086694
      Consensus CDS
      CCDS21351.1
      UniProtKB/Swiss-Prot
      Q0VGR7, Q3TX51, Q8BK43
      Related
      ENSMUSP00000052177.3, ENSMUST00000053950.10
      Conserved Domains (2) summary
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65123
      LRR_8; Leucine rich repeat

    RNA

    1. NR_028143.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so is unlikely to make a functional protein.
      Source sequence(s)
      AI663251, AK004904, BC086694
    2. NR_028144.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so is unlikely to make a functional protein.
      Source sequence(s)
      AI663251, BC052051, BC086694
      Related
      ENSMUST00000187953.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      67163158..67295084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541130.4XP_006541193.1  leucine-rich repeat-containing protein 28 isoform X3

      Conserved Domains (3) summary
      PRK15370
      Location:41281
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      COG4886
      Location:34157
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
    2. XM_036153393.1XP_036009286.1  leucine-rich repeat-containing protein 28 isoform X2

      Conserved Domains (2) summary
      PRK15370
      Location:8290
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
    3. XM_036153392.1XP_036009285.1  leucine-rich repeat-containing protein 28 isoform X1

      Conserved Domains (3) summary
      PRK15370
      Location:8232
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      PRK15387
      Location:132359
      PRK15387; type III secretion system effector E3 ubiquitin transferase SspH2
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
    4. XM_006541133.2XP_006541196.2  leucine-rich repeat-containing protein 28 isoform X4

      UniProtKB/TrEMBL
      Q8BVY5
      Conserved Domains (2) summary
      PRK15370
      Location:24194
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00031
      Location:2446
      LRR_1; leucine-rich repeat [structural motif]

    RNA

    1. XR_391360.4 RNA Sequence

    2. XR_004934174.1 RNA Sequence

    3. XR_004934173.1 RNA Sequence

    4. XR_004934175.1 RNA Sequence