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    Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 18640, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfkfb2provided by MGI
    Official Full Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2provided by MGI
    Primary source
    MGI:MGI:107815
    See related
    Ensembl:ENSMUSG00000026409 AllianceGenome:MGI:107815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930568D07Rik
    Summary
    Enables 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in several processes, including fructose 2,6-bisphosphate metabolic process; monocarboxylic acid metabolic process; and positive regulation of insulin secretion. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 6.3), frontal lobe adult (RPKM 5.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pfkfb2 in Genome Data Viewer
    Location:
    1 E4; 1 56.89 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130616780..130656990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130689043..130729253, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene complement component 4 binding protein Neighboring gene STARR-seq mESC enhancer starr_02200 Neighboring gene complement component 4 binding protein, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E1230 Neighboring gene YOD1 deubiquitinase Neighboring gene STARR-seq mESC enhancer starr_02204 Neighboring gene expressed sequence AA986860 Neighboring gene predicted gene 28857 Neighboring gene predicted gene 28856 Neighboring gene STARR-seq mESC enhancer starr_02205

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 6-phosphofructo-2-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 6-phosphofructo-2-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 6-phosphofructo-2-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose-2,6-bisphosphate 2-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fructose-2,6-bisphosphate 2-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
    Names
    6PF-2-K/Fru-2,6-P2ase 2
    6PF-2-K/Fru-2,6-P2ase heart-type isozyme
    PFK-2/FBPase-2 gene B
    PFK/FBPase 2
    NP_001155887.1
    NP_001155888.1
    NP_001355772.1
    NP_032851.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162415.1NP_001155887.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 2

      See identical proteins and their annotated locations for NP_001155887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC139231, AK029659, BC051014
      Consensus CDS
      CCDS48350.1
      UniProtKB/TrEMBL
      B2Z893, Q8CDS6
      Related
      ENSMUSP00000140355.2, ENSMUST00000189534.7
      Conserved Domains (3) summary
      pfam00300
      Location:254437
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:30251
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:42197
      AAA_33; AAA domain
    2. NM_001162416.1NP_001155888.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 3

      See identical proteins and their annotated locations for NP_001155888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, and the 5' and 3' splice patterns have not been determined. The resulting isoform (3) lacks an internal segment near the C-terminus, compared to isoform 1.
      Source sequence(s)
      BC051014, EU616667
      Consensus CDS
      CCDS48349.1
      UniProtKB/Swiss-Prot
      P70265, Q8VEI9
      UniProtKB/TrEMBL
      B2Z892
      Related
      ENSMUSP00000133073.3, ENSMUST00000050406.11
      Conserved Domains (3) summary
      pfam00300
      Location:254406
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:30251
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:42197
      AAA_33; AAA domain
    3. NM_001368843.1NP_001355772.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC139231
      Consensus CDS
      CCDS87871.1
      UniProtKB/TrEMBL
      A0A087WRG0, A0A087WRM7
      Related
      ENSMUSP00000140612.2, ENSMUST00000187089.7
      Conserved Domains (2) summary
      pfam00300
      Location:254437
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:31251
      6PF2K; 6-phosphofructo-2-kinase
    4. NM_008825.4NP_032851.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 1

      See identical proteins and their annotated locations for NP_032851.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and isoform 1.
      Source sequence(s)
      AC139231
      Consensus CDS
      CCDS35701.1
      UniProtKB/Swiss-Prot
      P70265, Q8VEI9
      UniProtKB/TrEMBL
      Q6GTL7
      Related
      ENSMUSP00000127587.3, ENSMUST00000169659.8
      Conserved Domains (3) summary
      pfam00300
      Location:254437
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:30251
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:42197
      AAA_33; AAA domain

    RNA

    1. NR_027859.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a distinct 3' splice pattern, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC139231, BC051014

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      130616780..130656990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)