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    Fbxo32 F-box protein 32 [ Mus musculus (house mouse) ]

    Gene ID: 67731, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fbxo32provided by MGI
    Official Full Name
    F-box protein 32provided by MGI
    Primary source
    MGI:MGI:1914981
    See related
    Ensembl:ENSMUSG00000022358 AllianceGenome:MGI:1914981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAFbx; Gm20361; ATROGIN1; 4833442G10Rik
    Summary
    Involved in response to denervation involved in regulation of muscle adaptation. Acts upstream of or within cellular response to dexamethasone stimulus. Located in Z disc and nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; male reproductive gland or organ; and sensory organ. Orthologous to human FBXO32 (F-box protein 32). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 14.0), colon adult (RPKM 13.9) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fbxo32 in Genome Data Viewer
    Location:
    15 D1; 15 24.43 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58039275..58078288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58175879..58214892, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23475 Neighboring gene N-terminal glutamine amidase 1 Neighboring gene predicted gene, 22488 Neighboring gene STARR-seq mESC enhancer starr_38749 Neighboring gene predicted gene, 36112 Neighboring gene predicted gene, 36193 Neighboring gene STARR-seq mESC enhancer starr_38751 Neighboring gene STARR-seq mESC enhancer starr_38752 Neighboring gene kelch-like 38

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCF ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box only protein 32
    Names
    atrogin 1
    muscle atrophy F-box protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026346.3NP_080622.1  F-box only protein 32

      See identical proteins and their annotated locations for NP_080622.1

      Status: VALIDATED

      Source sequence(s)
      AC113292, AK014793, BU921446
      Consensus CDS
      CCDS27491.1
      UniProtKB/Swiss-Prot
      Q9CPU7
      Related
      ENSMUSP00000022986.7, ENSMUST00000022986.8
      Conserved Domains (1) summary
      pfam06881
      Location:257302
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58039275..58078288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)