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    Trim62 tripartite motif-containing 62 [ Mus musculus (house mouse) ]

    Gene ID: 67525, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim62provided by MGI
    Official Full Name
    tripartite motif-containing 62provided by MGI
    Primary source
    MGI:MGI:1914775
    See related
    Ensembl:ENSMUSG00000041000 AllianceGenome:MGI:1914775
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dear1; 6330414G21Rik
    Summary
    Predicted to enable identical protein binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in positive regulation of antifungal innate immune response. Acts upstream of or within negative regulation of epithelial to mesenchymal transition. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; maxillary process; sensory organ; and submandibular gland primordium. Orthologous to human TRIM62 (tripartite motif containing 62). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 21.1), ovary adult (RPKM 7.9) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Trim62 in Genome Data Viewer
    Location:
    4 D2.2; 4 62.38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128777837..128805119)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128884044..128911326)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 33814 Neighboring gene predicted gene, 54259 Neighboring gene predicted gene, 33901 Neighboring gene STARR-positive B cell enhancer ABC_E6221 Neighboring gene predicted gene, 57685

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of viral transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of antifungal innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of antifungal innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K27-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K27-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in viral release from host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral release from host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM62
    Names
    RING-type E3 ubiquitin transferase TRIM62
    tripartite motif-containing protein 62
    NP_001357685.1
    NP_001357686.1
    NP_835211.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370756.1NP_001357685.1  E3 ubiquitin-protein ligase TRIM62 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL607086
      Conserved Domains (4) summary
      COG1196
      Location:133267
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13744
      Location:290477
      SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)
      pfam00643
      Location:91128
      zf-B_box; B-box zinc finger
      cd16608
      Location:655
      RING-HC_TRIM62_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 62 (TRIM62) and similar proteins
    2. NM_001370757.1NP_001357686.1  E3 ubiquitin-protein ligase TRIM62 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL607086
      Conserved Domains (4) summary
      smart00502
      Location:128223
      BBC; B-Box C-terminal domain
      TIGR00599
      Location:9148
      rad18; DNA repair protein rad18
      cd13744
      Location:252439
      SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)
      cd16608
      Location:655
      RING-HC_TRIM62_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 62 (TRIM62) and similar proteins
    3. NM_178110.3NP_835211.1  E3 ubiquitin-protein ligase TRIM62 isoform 2

      See identical proteins and their annotated locations for NP_835211.1

      Status: VALIDATED

      Source sequence(s)
      AL607086
      Consensus CDS
      CCDS18677.1
      UniProtKB/Swiss-Prot
      Q80V85
      Related
      ENSMUSP00000039121.9, ENSMUST00000035667.9
      Conserved Domains (4) summary
      pfam00643
      Location:91128
      zf-B_box; B-box zinc finger
      cd13744
      Location:284471
      SPRY_PRY_TRIM62; PRY/SPRY domain in tripartite motif-binding protein 62 (TRIM62)
      cl17238
      Location:1153
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl23765
      Location:136255
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      128777837..128805119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)