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    Ckap2l cytoskeleton associated protein 2-like [ Mus musculus (house mouse) ]

    Gene ID: 70466, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ckap2lprovided by MGI
    Official Full Name
    cytoskeleton associated protein 2-likeprovided by MGI
    Primary source
    MGI:MGI:1917716
    See related
    Ensembl:ENSMUSG00000048327 AllianceGenome:MGI:1917716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    rdm; radmis; 2010016H04Rik; 2610318C08Rik
    Summary
    Predicted to be located in microtubule cytoskeleton. Predicted to be active in centrosome; cytosol; and mitotic spindle. Is expressed in brain ventricular layer; forebrain; nephrogenic zone; and thymus primordium. Human ortholog(s) of this gene implicated in Filippi syndrome. Orthologous to human CKAP2L (cytoskeleton associated protein 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14 (RPKM 7.7), CNS E11.5 (RPKM 7.0) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ckap2l in Genome Data Viewer
    Location:
    2 F1; 2 62.87 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129110130..129139148, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129268210..129297228, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3404 Neighboring gene solute carrier family 20, member 1 Neighboring gene RIKEN cDNA A730036I17 gene Neighboring gene STARR-seq mESC enhancer starr_05664 Neighboring gene STARR-seq mESC enhancer starr_05666 Neighboring gene STARR-positive B cell enhancer ABC_E5981 Neighboring gene STARR-positive B cell enhancer ABC_E7862 Neighboring gene STARR-seq mESC enhancer starr_05668 Neighboring gene predicted gene 14023 Neighboring gene interleukin 1 alpha Neighboring gene predicted gene, 29941 Neighboring gene predicted gene, 25703

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in CKAP2L, the human homolog of the mouse Radmis gene, cause Filippi syndrome. Hussain MS, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439729, Free PMC Article
    2. Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors. Yumoto T, et al. PLoS One, 2013. PMID 24260314, Free PMC Article
    3. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Kumada T, et al. Dev Dyn, 2010 Aug. PMID 20568244
    4. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Sincennes MC, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26764384, Free PMC Article
    5. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, et al. Genomics, 2004 Nov. PMID 15475267

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytoskeleton-associated protein 2-like
    Names
    radial fiber and mitotic spindle protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181589.3 → NP_853620.1  cytoskeleton-associated protein 2-like

      See identical proteins and their annotated locations for NP_853620.1

      Status: VALIDATED

      Source sequence(s)
      AL772347, BC053443, CO042920, CV560846, CX205381
      Consensus CDS
      CCDS16724.1
      UniProtKB/Swiss-Prot
      Q3U5A3, Q7TS74, Q8K264, U6C6D6
      Related
      ENSMUSP00000056145.7, ENSMUST00000052708.7
      Conserved Domains (1) summary
      pfam15297
      Location:435 → 734
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      129110130..129139148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500158.5 → XP_006500221.1  cytoskeleton-associated protein 2-like isoform X1

      Conserved Domains (1) summary
      pfam15297
      Location:436 → 733
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    2. XM_030252067.2 → XP_030107927.1  cytoskeleton-associated protein 2-like isoform X2

      Conserved Domains (1) summary
      pfam15297
      Location:387 → 685
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

    3. XM_036162563.1 → XP_036018456.1  cytoskeleton-associated protein 2-like isoform X3

      Conserved Domains (1) summary
      pfam15297
      Location:387 → 684
      CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TS74.1 GenPept UniProtKB/Swiss-Prot:Q7TS74

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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