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    Selenoo selenoprotein O [ Mus musculus (house mouse) ]

    Gene ID: 223776, updated on 9-Dec-2024

    Summary

    Official Symbol
    Selenooprovided by MGI
    Official Full Name
    selenoprotein Oprovided by MGI
    Primary source
    MGI:MGI:1919007
    See related
    Ensembl:ENSMUSG00000035757 AllianceGenome:MGI:1919007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Selo; 1300018J18Rik
    Summary
    This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 58.1), liver adult (RPKM 45.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Selenoo in Genome Data Viewer
    Location:
    15 E3; 15 44.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88973241..88984542)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89089038..89100339)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene pannexin 2 Neighboring gene RIKEN cDNA 1810021B22 gene Neighboring gene TraB domain containing Neighboring gene tubulin, gamma complex component 6 Neighboring gene STARR-positive B cell enhancer ABC_E5508 Neighboring gene histone deacetylase 10 Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AMPylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMPylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein adenylylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein adenylyltransferase SelO, mitochondrial
    NP_082181.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027905.3NP_082181.2  protein adenylyltransferase SelO, mitochondrial

      See identical proteins and their annotated locations for NP_082181.2

      Status: REVIEWED

      Source sequence(s)
      AK005048, AW060160, BE864360, BQ177186
      Consensus CDS
      CCDS27738.1
      UniProtKB/Swiss-Prot
      E9QPP4, Q80ZK3, Q9DBC0
      UniProtKB/TrEMBL
      B9EJ24
      Related
      ENSMUSP00000081020.6, ENSMUST00000082439.6
      Conserved Domains (1) summary
      cl19499
      Location:42667
      UPF0061; Uncharacterized ACR, YdiU/UPF0061 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      88973241..88984542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)