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    Elovl1 ELOVL fatty acid elongase 1 [ Mus musculus (house mouse) ]

    Gene ID: 54325, updated on 3-Dec-2024

    Summary

    Official Symbol
    Elovl1provided by MGI
    Official Full Name
    ELOVL fatty acid elongase 1provided by MGI
    Primary source
    MGI:MGI:1858959
    See related
    Ensembl:ENSMUSG00000006390 AllianceGenome:MGI:1858959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ssc1
    Summary
    Predicted to enable fatty acid elongase activity. Involved in ceramide biosynthetic process and establishment of skin barrier. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; liver; skin; spleen; and upper jaw. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 166.7), stomach adult (RPKM 78.7) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Elovl1 in Genome Data Viewer
    Location:
    4 D2.1; 4 54.61 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (118285321..118290150)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (118426874..118432953)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hydroxypyruvate isomerase (putative) Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene STARR-positive B cell enhancer ABC_E1281 Neighboring gene mediator complex subunit 8 Neighboring gene STARR-positive B cell enhancer ABC_E6202 Neighboring gene cell division cycle 20 Neighboring gene myeloproliferative leukemia virus oncogene Neighboring gene tyrosine kinase with immunoglobulin-like and EGF-like domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid elongase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, monounsaturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid elongation, monounsaturated fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, saturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid elongation, saturated fatty acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in very long-chain fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    very long chain fatty acid elongase 1
    Names
    3-keto acyl-CoA synthase Elovl1
    ELOVL FA elongase 1
    elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
    elongation of very long chain fatty acids protein 1
    sequence similarity to Cig30 1
    very long chain 3-ketoacyl-CoA synthase 1
    very long chain 3-oxoacyl-CoA synthase 1
    NP_001034264.1
    NP_001034265.1
    NP_001411916.1
    NP_001411917.1
    NP_001411918.1
    NP_062295.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039175.3NP_001034264.1  very long chain fatty acid elongase 1 isoform 2

      See identical proteins and their annotated locations for NP_001034264.1

      Status: VALIDATED

      Source sequence(s)
      AL627212
      Consensus CDS
      CCDS18550.1
      UniProtKB/TrEMBL
      Q4V9V3, Q9WU14
      Related
      ENSMUSP00000099734.5, ENSMUST00000102673.11
      Conserved Domains (1) summary
      pfam01151
      Location:3183
      ELO; GNS1/SUR4 family
    2. NM_001039176.3NP_001034265.1  very long chain fatty acid elongase 1 isoform 1

      See identical proteins and their annotated locations for NP_001034265.1

      Status: VALIDATED

      Source sequence(s)
      AL627212
      Consensus CDS
      CCDS18549.1
      UniProtKB/Swiss-Prot
      Q9D1B2, Q9JLJ5
      UniProtKB/TrEMBL
      Q548M4
      Related
      ENSMUSP00000064816.4, ENSMUST00000067896.4
      Conserved Domains (1) summary
      pfam01151
      Location:23260
      ELO; GNS1/SUR4 family
    3. NM_001424987.1NP_001411916.1  very long chain fatty acid elongase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627212
      UniProtKB/TrEMBL
      Q4V9V3, Q9WU14
    4. NM_001424988.1NP_001411917.1  very long chain fatty acid elongase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627212
      UniProtKB/Swiss-Prot
      Q9D1B2, Q9JLJ5
      UniProtKB/TrEMBL
      Q548M4
    5. NM_001424989.1NP_001411918.1  very long chain fatty acid elongase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627212
    6. NM_019422.4NP_062295.1  very long chain fatty acid elongase 1 isoform 1

      See identical proteins and their annotated locations for NP_062295.1

      Status: VALIDATED

      Source sequence(s)
      AL627212
      Consensus CDS
      CCDS18549.1
      UniProtKB/Swiss-Prot
      Q9D1B2, Q9JLJ5
      UniProtKB/TrEMBL
      Q548M4
      Related
      ENSMUSP00000006557.7, ENSMUST00000006557.13
      Conserved Domains (1) summary
      pfam01151
      Location:23260
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      118285321..118290150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)