TAD2 tRNA(adenine34) deaminase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TAD2
Official Full Name: tRNA(adenine34) deaminase
Primary source: SGD:S000003572
Locus tag: YJL035C
See related: AllianceGenome:SGD:S000003572; FungiDB:YJL035C; VEuPathDB:YJL035C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables tRNA-specific adenosine deaminase activity. Involved in tRNA modification. Located in cytoplasm and nucleus. Orthologous to human ADAT2 (adenosine deaminase tRNA specific 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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The CGA codon decoding through tRNA[Arg] (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
Title: The CGA codon decoding through tRNA(Arg) (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
Crystal structure of the ADAT2-ADAT3 heterodimer. [ADAT2, ADAT3]
Title: Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables deaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tRNA-specific adenosine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA-specific adenosine-34 deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-specific adenosine-34 deaminase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleobase-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble adenosine to inosine editing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

NP_012499.1

Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs

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