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    EWSR1 EWS RNA binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 2130, updated on 27-Nov-2024

    Summary

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    Official Symbol
    EWSR1provided by HGNC
    Official Full Name
    EWS RNA binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:3508
    See related
    Ensembl:ENSG00000182944 MIM:133450; AllianceGenome:HGNC:3508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EWS; EWS-FLI1; bK984G1.4
    Summary
    This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
    Expression
    Ubiquitous expression in testis (RPKM 27.8), bone marrow (RPKM 27.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EWSR1 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (29268268..29300521)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (29731759..29763936)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29664257..29696511)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene EMI domain containing 1 Neighboring gene uncharacterized LOC105372985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29619669-29620170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29629634-29630134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29630135-29630635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29655585-29656439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29656440-29657293 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29663849-29664720 Neighboring gene rhomboid domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29698939-29699439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29701647-29702392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29702393-29703136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29710073-29710877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29710878-29711682 Neighboring gene growth arrest specific 2 like 1 Neighboring gene RAS like family 10 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. EWSR1 rearrangement in papillary thyroid microcarcinoma is related to classic morphology and the presence of small-cell phenotype. Kovacevic B, et al. Bosn J Basic Med Sci, 2022 Feb 1. PMID 34374640, Free PMC Article
    2. Primary round cell sarcomas of the urinary bladder with EWSR1 rearrangement: a multi-institutional study of thirteen cases with a review of the literature. Baisakh MR, et al. Hum Pathol, 2020 Oct. PMID 32798549
    3. The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review. Fisher C. Histopathology, 2014 Jan. PMID 24320889
    4. EWSR1 overexpression is a pro-oncogenic event in multiple myeloma. Nishiyama D, et al. Int J Hematol, 2021 Mar. PMID 33095415
    5. Clinicopathological and molecular spectrum of ewing sarcomas/PNETs, including validation of EWSR1 rearrangement by conventional and array FISH technique in certain cases. Rekhi B, et al. Pathol Oncol Res, 2014 Jul. PMID 24293381

    See all (485) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement.
      Title: Concurrent ependymal and ganglionic differentiation in a subset of supratentorial neuroepithelial tumors with EWSR1-PLAGL1 rearrangement.
    2. EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
      Title: EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.
    3. Superficial Neurocristic EWSR1::FLI1 Fusion Tumor: A Distinctive, Clinically Indolent, S100 Protein/SOX10-Positive Neoplasm.
      Title: Superficial Neurocristic EWSR1::FLI1 Fusion Tumor: A Distinctive, Clinically Indolent, S100 Protein/SOX10-Positive Neoplasm.
    4. Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.
      Title: Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma.
    5. Carcinomas with clear cell features and EWSR1 rearrangements: a report of 3 cases.
      Title: Carcinomas with clear cell features and EWSR1 rearrangements: a report of 3 cases.
    6. Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse.
      Title: Central nervous system embryonal tumors with EWSR1-PLAGL1 rearrangements reclassified as INI-1 deficient tumors at relapse.
    7. Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks.
      Title: Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks.
    8. Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors.
      Title: Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors.
    9. Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription.
      Title: Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription.
    10. EWSR1::WT1 Fusions in Neoplasms Other Than Conventional Desmoplastic Small Round Cell Tumor: Three Tumors Occurring Outside the Female Genital Tract.
      Title: EWSR1::WT1 Fusions in Neoplasms Other Than Conventional Desmoplastic Small Round Cell Tumor: Three Tumors Occurring Outside the Female Genital Tract.
    Submit: New GeneRIF Correction See all GeneRIFs (256)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Ewing sarcoma
    MedGen: C0553580 OMIM: 612219 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    EBI GWAS Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, Ewing sarcoma breakpoint region 1 (EWSR1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with EWSR1 is increased by RRE PubMed
    Vpr vpr HIV-1 Vpr upregulates EWSR1 in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein EWS
    Names
    Ewing sarcoma breakpoint region 1
    Ewings sarcoma EWS-Fli1 (type 1) oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023240.2 RefSeqGene

      Range
      5002..37255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001163285.2 → NP_001156757.1  RNA-binding protein EWS isoform 3

      See identical proteins and their annotated locations for NP_001156757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK225102, AW205707, BC004817, DB443651
      Consensus CDS
      CCDS54513.1
      UniProtKB/TrEMBL
      B0QYK0
      Related
      ENSP00000385726.1, ENST00000406548.5
      Conserved Domains (4) summary
      COG0724
      Location:349 → 457
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:360 → 443
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:521 → 542
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:517 → 546
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. NM_001163286.2 → NP_001156758.1  RNA-binding protein EWS isoform 4

      See identical proteins and their annotated locations for NP_001156758.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AK056681, AW205707, DA051447, DB443651
      Consensus CDS
      CCDS54514.1
      UniProtKB/TrEMBL
      B0QYK0
      Related
      ENSP00000331699.6, ENST00000332035.10
      Conserved Domains (4) summary
      COG0724
      Location:294 → 402
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:305 → 388
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:466 → 487
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:462 → 491
      zf-RanBP; Zn-finger in Ran binding protein and others

    3. NM_001163287.2 → NP_001156759.1  RNA-binding protein EWS isoform 5

      See identical proteins and their annotated locations for NP_001156759.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, and differs in the 3' UTR and in the presence and absence of exons in the 3' coding region, compared to variant 1. The resulting isoform (5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC000527, DB443651
      Consensus CDS
      CCDS54512.1
      UniProtKB/Swiss-Prot
      Q01844
      Related
      ENSP00000327456.6, ENST00000333395.11
      Conserved Domains (1) summary
      PHA03247
      Location:71 → 206
      PHA03247; large tegument protein UL36; Provisional

    4. NM_005243.4 → NP_005234.1  RNA-binding protein EWS isoform 2

      See identical proteins and their annotated locations for NP_005234.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AW205707, BC004817, DB443651
      Consensus CDS
      CCDS13851.1
      UniProtKB/Swiss-Prot
      B0QYK1, Q01844, Q5THL0, Q92635, Q96FE8, Q96MN4, Q96MX4, Q9BWA2
      UniProtKB/TrEMBL
      B0QYK0
      Related
      ENSP00000381031.2, ENST00000397938.7
      Conserved Domains (4) summary
      COG0724
      Location:350 → 458
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:361 → 444
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:522 → 543
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:518 → 547
      zf-RanBP; Zn-finger in Ran binding protein and others

    5. NM_013986.4 → NP_053733.2  RNA-binding protein EWS isoform 1

      See identical proteins and their annotated locations for NP_053733.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK056309, AW205707, DB443651
      Consensus CDS
      CCDS13852.2
      UniProtKB/TrEMBL
      B0QYK0
      Related
      ENSP00000400142.2, ENST00000414183.6
      Conserved Domains (4) summary
      COG0724
      Location:355 → 463
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:366 → 449
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:527 → 548
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:523 → 552
      zf-RanBP; Zn-finger in Ran binding protein and others

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      29268268..29300521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529995.4 → XP_011528297.1  RNA-binding protein EWS isoform X1

      UniProtKB/TrEMBL
      B0QYK0
      Conserved Domains (4) summary
      COG0724
      Location:351 → 459
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:362 → 445
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:523 → 557
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:519 → 561
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. XM_011529999.4 → XP_011528301.1  RNA-binding protein EWS isoform X7

      Conserved Domains (4) summary
      COG0724
      Location:351 → 459
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:362 → 445
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:523 → 557
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:519 → 557
      zf-RanBP; Zn-finger in Ran binding protein and others

    3. XM_011529997.3 → XP_011528299.1  RNA-binding protein EWS isoform X5

      UniProtKB/TrEMBL
      B0QYK0
      Conserved Domains (4) summary
      COG0724
      Location:351 → 459
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:362 → 445
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:523 → 544
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:519 → 548
      zf-RanBP; Zn-finger in Ran binding protein and others

    4. XM_011530000.3 → XP_011528302.1  RNA-binding protein EWS isoform X11

      Conserved Domains (4) summary
      COG0724
      Location:351 → 459
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:362 → 445
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:523 → 544
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:519 → 544
      zf-RanBP; Zn-finger in Ran binding protein and others

    5. XM_017028649.3 → XP_016884138.1  RNA-binding protein EWS isoform X15

      UniProtKB/TrEMBL
      B0QYK0
      Conserved Domains (4) summary
      smart00547
      Location:480 → 519
      ZnF_RBZ; Zinc finger domain
      PHA03247
      Location:72 → 207
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:482 → 516
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cl17169
      Location:364 → 431
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_047441190.1 → XP_047297146.1  RNA-binding protein EWS isoform X26

    7. XM_017028650.3 → XP_016884139.1  RNA-binding protein EWS isoform X18

      UniProtKB/TrEMBL
      B0QYK0

    8. XM_047441192.1 → XP_047297148.1  RNA-binding protein EWS isoform X31

    9. XM_011529996.4 → XP_011528298.1  RNA-binding protein EWS isoform X3

      UniProtKB/TrEMBL
      B0QYK0
      Conserved Domains (4) summary
      COG0724
      Location:350 → 458
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:361 → 444
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:522 → 556
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:518 → 560
      zf-RanBP; Zn-finger in Ran binding protein and others

    10. XM_017028646.3 → XP_016884135.1  RNA-binding protein EWS isoform X9

    11. XM_011529998.3 → XP_011528300.1  RNA-binding protein EWS isoform X6

      UniProtKB/TrEMBL
      B0QYK0
      Conserved Domains (4) summary
      COG0724
      Location:350 → 458
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:361 → 444
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:522 → 543
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:518 → 547
      zf-RanBP; Zn-finger in Ran binding protein and others

    12. XM_047441187.1 → XP_047297143.1  RNA-binding protein EWS isoform X13

    13. XM_017028652.3 → XP_016884141.1  RNA-binding protein EWS isoform X20

      UniProtKB/TrEMBL
      B0QYK0

    14. XM_011530002.4 → XP_011528304.1  RNA-binding protein EWS isoform X33

      UniProtKB/TrEMBL
      C9JGE3, V5JZ30
      Conserved Domains (4) summary
      COG0724
      Location:278 → 386
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:289 → 372
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:450 → 484
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:446 → 488
      zf-RanBP; Zn-finger in Ran binding protein and others

    15. XM_024452180.2 → XP_024307948.1  RNA-binding protein EWS isoform X40

      Conserved Domains (4) summary
      cd12533
      Location:289 → 372
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00030
      Location:465 → 484
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:446 → 484
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl26464
      Location:72 → 207
      Atrophin-1; Atrophin-1 family

    16. XM_047441195.1 → XP_047297151.1  RNA-binding protein EWS isoform X36

      UniProtKB/TrEMBL
      A0A0D9SFL3
      Related
      ENSP00000486709.1, ENST00000629659.2

    17. XM_047441199.1 → XP_047297155.1  RNA-binding protein EWS isoform X44

    18. XM_011530001.3 → XP_011528303.1  RNA-binding protein EWS isoform X22

      Conserved Domains (4) summary
      COG0724
      Location:295 → 403
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:306 → 389
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:467 → 501
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:463 → 505
      zf-RanBP; Zn-finger in Ran binding protein and others

    19. XM_047441191.1 → XP_047297147.1  RNA-binding protein EWS isoform X28

    20. XM_017028654.2 → XP_016884143.1  RNA-binding protein EWS isoform X24

    21. XM_017028658.2 → XP_016884147.1  RNA-binding protein EWS isoform X29

    22. XM_005261389.5 → XP_005261446.1  RNA-binding protein EWS isoform X2

      UniProtKB/TrEMBL
      B0QYK0
      Conserved Domains (4) summary
      COG0724
      Location:350 → 458
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:361 → 444
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:522 → 556
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:518 → 560
      zf-RanBP; Zn-finger in Ran binding protein and others

    23. XM_017028645.3 → XP_016884134.1  RNA-binding protein EWS isoform X8

      UniProtKB/TrEMBL
      B0QYK0

    24. XM_047441186.1 → XP_047297142.1  RNA-binding protein EWS isoform X12

    25. XM_047441188.1 → XP_047297144.1  RNA-binding protein EWS isoform X16

    26. XM_017028656.3 → XP_016884145.1  RNA-binding protein EWS isoform X27

      UniProtKB/TrEMBL
      B0QYK0

    27. XM_017028651.3 → XP_016884140.1  RNA-binding protein EWS isoform X19

      UniProtKB/TrEMBL
      B0QYK0

    28. XM_017028644.3 → XP_016884133.1  RNA-binding protein EWS isoform X4

      UniProtKB/TrEMBL
      B0QYK0

    29. XM_017028647.3 → XP_016884136.1  RNA-binding protein EWS isoform X10

      UniProtKB/TrEMBL
      B0QYK0

    30. XM_017028648.3 → XP_016884137.1  RNA-binding protein EWS isoform X14

      UniProtKB/TrEMBL
      B0QYK0

    31. XM_047441189.1 → XP_047297145.1  RNA-binding protein EWS isoform X17

    32. XM_017028653.3 → XP_016884142.1  RNA-binding protein EWS isoform X21

      UniProtKB/TrEMBL
      B0QYK0

    33. XM_017028660.3 → XP_016884149.1  RNA-binding protein EWS isoform X32

      UniProtKB/TrEMBL
      B0QYK0

    34. XM_047441193.1 → XP_047297149.1  RNA-binding protein EWS isoform X34

    35. XM_047441198.1 → XP_047297154.1  RNA-binding protein EWS isoform X41

    36. XM_047441196.1 → XP_047297152.1  RNA-binding protein EWS isoform X37

      Related
      ENSP00000330896.7, ENST00000332050.10

    37. XM_024452181.2 → XP_024307949.1  RNA-binding protein EWS isoform X42

      UniProtKB/TrEMBL
      C9JGE3, V5JZ30
      Conserved Domains (4) summary
      cd12533
      Location:288 → 371
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:449 → 470
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:445 → 470
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl26464
      Location:71 → 206
      Atrophin-1; Atrophin-1 family

    38. XM_047441200.1 → XP_047297156.1  RNA-binding protein EWS isoform X45

    39. XM_005261390.5 → XP_005261447.1  RNA-binding protein EWS isoform X23

      UniProtKB/TrEMBL
      B0QYK0
      Conserved Domains (4) summary
      COG0724
      Location:294 → 402
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:305 → 388
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:466 → 500
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:462 → 504
      zf-RanBP; Zn-finger in Ran binding protein and others

    40. XM_047441194.1 → XP_047297150.1  RNA-binding protein EWS isoform X35

    41. XM_047441197.1 → XP_047297153.1  RNA-binding protein EWS isoform X38

    42. XM_017028655.2 → XP_016884144.1  RNA-binding protein EWS isoform X25

      UniProtKB/TrEMBL
      B0QYK0

    43. XM_017028659.2 → XP_016884148.1  RNA-binding protein EWS isoform X30

      UniProtKB/TrEMBL
      B0QYK0

    44. XM_017028662.3 → XP_016884151.1  RNA-binding protein EWS isoform X39

    45. XM_017028663.2 → XP_016884152.1  RNA-binding protein EWS isoform X43

      UniProtKB/TrEMBL
      B0QYK0

    46. XM_047441201.1 → XP_047297157.1  RNA-binding protein EWS isoform X46

    47. XM_047441202.1 → XP_047297158.1  RNA-binding protein EWS isoform X47

      Related
      ENSP00000412670.2, ENST00000437155.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      29731759..29763936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325228.1 → XP_054181203.1  RNA-binding protein EWS isoform X1

    2. XM_054325234.1 → XP_054181209.1  RNA-binding protein EWS isoform X7

    3. XM_054325232.1 → XP_054181207.1  RNA-binding protein EWS isoform X5

    4. XM_054325238.1 → XP_054181213.1  RNA-binding protein EWS isoform X11

    5. XM_054325242.1 → XP_054181217.1  RNA-binding protein EWS isoform X15

    6. XM_054325253.1 → XP_054181228.1  RNA-binding protein EWS isoform X26

    7. XM_054325245.1 → XP_054181220.1  RNA-binding protein EWS isoform X18

    8. XM_054325258.1 → XP_054181233.1  RNA-binding protein EWS isoform X31

    9. XM_054325230.1 → XP_054181205.1  RNA-binding protein EWS isoform X3

    10. XM_054325236.1 → XP_054181211.1  RNA-binding protein EWS isoform X9

    11. XM_054325233.1 → XP_054181208.1  RNA-binding protein EWS isoform X6

    12. XM_054325240.1 → XP_054181215.1  RNA-binding protein EWS isoform X13

    13. XM_054325247.1 → XP_054181222.1  RNA-binding protein EWS isoform X20

    14. XM_054325260.1 → XP_054181235.1  RNA-binding protein EWS isoform X33

    15. XM_054325267.1 → XP_054181242.1  RNA-binding protein EWS isoform X40

    16. XM_054325263.1 → XP_054181238.1  RNA-binding protein EWS isoform X36

      UniProtKB/TrEMBL
      A0A0D9SFL3

    17. XM_054325271.1 → XP_054181246.1  RNA-binding protein EWS isoform X44

    18. XM_054325249.1 → XP_054181224.1  RNA-binding protein EWS isoform X22

    19. XM_054325255.1 → XP_054181230.1  RNA-binding protein EWS isoform X28

    20. XM_054325251.1 → XP_054181226.1  RNA-binding protein EWS isoform X24

    21. XM_054325256.1 → XP_054181231.1  RNA-binding protein EWS isoform X29

    22. XM_054325229.1 → XP_054181204.1  RNA-binding protein EWS isoform X2

    23. XM_054325235.1 → XP_054181210.1  RNA-binding protein EWS isoform X8

    24. XM_054325239.1 → XP_054181214.1  RNA-binding protein EWS isoform X12

    25. XM_054325243.1 → XP_054181218.1  RNA-binding protein EWS isoform X16

    26. XM_054325254.1 → XP_054181229.1  RNA-binding protein EWS isoform X27

    27. XM_054325246.1 → XP_054181221.1  RNA-binding protein EWS isoform X19

    28. XM_054325231.1 → XP_054181206.1  RNA-binding protein EWS isoform X4

    29. XM_054325237.1 → XP_054181212.1  RNA-binding protein EWS isoform X10

    30. XM_054325241.1 → XP_054181216.1  RNA-binding protein EWS isoform X14

    31. XM_054325244.1 → XP_054181219.1  RNA-binding protein EWS isoform X17

    32. XM_054325248.1 → XP_054181223.1  RNA-binding protein EWS isoform X21

    33. XM_054325259.1 → XP_054181234.1  RNA-binding protein EWS isoform X32

    34. XM_054325261.1 → XP_054181236.1  RNA-binding protein EWS isoform X34

    35. XM_054325268.1 → XP_054181243.1  RNA-binding protein EWS isoform X41

    36. XM_054325264.1 → XP_054181239.1  RNA-binding protein EWS isoform X37

    37. XM_054325269.1 → XP_054181244.1  RNA-binding protein EWS isoform X42

    38. XM_054325272.1 → XP_054181247.1  RNA-binding protein EWS isoform X45

    39. XM_054325250.1 → XP_054181225.1  RNA-binding protein EWS isoform X23

    40. XM_054325262.1 → XP_054181237.1  RNA-binding protein EWS isoform X35

    41. XM_054325265.1 → XP_054181240.1  RNA-binding protein EWS isoform X38

    42. XM_054325252.1 → XP_054181227.1  RNA-binding protein EWS isoform X25

    43. XM_054325257.1 → XP_054181232.1  RNA-binding protein EWS isoform X30

    44. XM_054325266.1 → XP_054181241.1  RNA-binding protein EWS isoform X39

    45. XM_054325270.1 → XP_054181245.1  RNA-binding protein EWS isoform X43

    46. XM_054325273.1 → XP_054181248.1  RNA-binding protein EWS isoform X46

    47. XM_054325274.1 → XP_054181249.1  RNA-binding protein EWS isoform X47

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01844.1 GenPept UniProtKB/Swiss-Prot:Q01844

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