U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TMEM131L transmembrane 131 like [ Homo sapiens (human) ]

    Gene ID: 23240, updated on 3-Dec-2024

    Summary

    Official Symbol
    TMEM131Lprovided by HGNC
    Official Full Name
    transmembrane 131 likeprovided by HGNC
    Primary source
    HGNC:HGNC:29146
    See related
    Ensembl:ENSG00000121210 MIM:616243; AllianceGenome:HGNC:29146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA0922
    Summary
    Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lymph node (RPKM 22.3), bone marrow (RPKM 15.4) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TMEM131L in Genome Data Viewer
    Location:
    4q31.3
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153466360..153636711)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (156790800..156961149)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154387512..154557863)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22052 Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene meiotic nuclear divisions 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154388523-154389188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390454-154390954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390955-154391455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154415607-154416604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154433973-154434472 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154442146-154442647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22069 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:154444154-154444994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15763 Neighboring gene uncharacterized LOC105377498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154455569-154456145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154456146-154456721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:154457236-154457741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15764 Neighboring gene toll like receptor 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154561385-154561884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15767 Neighboring gene WD repeat domain 45 pseudogene 1 Neighboring gene toll like receptor 2 Neighboring gene ring finger protein 175

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of KIAA0922 by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with KIAA0922 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10592, DKFZp586H1322

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane protein 131-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131007.2NP_001124479.1  transmembrane protein 131-like isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AK092270, AK096538, AK308448, BC044932
      Consensus CDS
      CCDS47148.1
      UniProtKB/TrEMBL
      H0Y2M0
      Related
      ENSP00000386787.3, ENST00000409959.8
      Conserved Domains (1) summary
      cl13764
      Location:91174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    2. NM_015196.4NP_056011.3  transmembrane protein 131-like isoform 2 precursor

      See identical proteins and their annotated locations for NP_056011.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      BC131505, BQ270562, DA778851
      Consensus CDS
      CCDS3783.2
      UniProtKB/Swiss-Prot
      A2VDJ0, B3KRV3, D3DP10, Q7LGA7, Q86Y92, Q8WU56, Q9H065, Q9Y2D7
      UniProtKB/TrEMBL
      H0Y2M0
      Related
      ENSP00000386574.3, ENST00000409663.7
      Conserved Domains (2) summary
      pfam19532
      Location:1851609
      TMEM131_like; Transmembrane protein 131-like
      cl13764
      Location:91174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      153466360..153636711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449899.1XP_047305855.1  transmembrane protein 131-like isoform X1

      UniProtKB/TrEMBL
      H0Y2M0
    2. XM_011531780.2XP_011530082.1  transmembrane protein 131-like isoform X4

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:120203
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    3. XM_047449901.1XP_047305857.1  transmembrane protein 131-like isoform X3

      UniProtKB/TrEMBL
      H0Y2M0
    4. XM_047449902.1XP_047305858.1  transmembrane protein 131-like isoform X6

      UniProtKB/TrEMBL
      H0Y2M0
    5. XM_047449917.1XP_047305873.1  transmembrane protein 131-like isoform X25

      UniProtKB/TrEMBL
      H0Y2M0
    6. XM_011531783.2XP_011530085.1  transmembrane protein 131-like isoform X28

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:120203
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    7. XM_047449920.1XP_047305876.1  transmembrane protein 131-like isoform X29

      UniProtKB/TrEMBL
      H0Y2M0
    8. XM_047449900.1XP_047305856.1  transmembrane protein 131-like isoform X2

      UniProtKB/TrEMBL
      H0Y2M0
    9. XM_011531781.2XP_011530083.1  transmembrane protein 131-like isoform X5

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:120203
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    10. XM_047449903.1XP_047305859.1  transmembrane protein 131-like isoform X7

      UniProtKB/TrEMBL
      H0Y2M0
    11. XM_047449918.1XP_047305874.1  transmembrane protein 131-like isoform X26

      UniProtKB/TrEMBL
      H0Y2M0
    12. XM_047449919.1XP_047305875.1  transmembrane protein 131-like isoform X27

      UniProtKB/TrEMBL
      H0Y2M0
    13. XM_047449904.1XP_047305860.1  transmembrane protein 131-like isoform X8

      UniProtKB/TrEMBL
      H0Y2M0
    14. XM_047449908.1XP_047305864.1  transmembrane protein 131-like isoform X14

      UniProtKB/TrEMBL
      H0Y2M0
    15. XM_047449909.1XP_047305865.1  transmembrane protein 131-like isoform X15

      UniProtKB/TrEMBL
      H0Y2M0
    16. XM_047449905.1XP_047305861.1  transmembrane protein 131-like isoform X9

      UniProtKB/TrEMBL
      H0Y2M0
    17. XM_047449910.1XP_047305866.1  transmembrane protein 131-like isoform X16

      UniProtKB/TrEMBL
      H0Y2M0
    18. XM_024453956.2XP_024309724.1  transmembrane protein 131-like isoform X10

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:91174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    19. XM_047449906.1XP_047305862.1  transmembrane protein 131-like isoform X11

      UniProtKB/TrEMBL
      H0Y2M0
    20. XM_017007925.2XP_016863414.1  transmembrane protein 131-like isoform X17

      UniProtKB/TrEMBL
      H0Y2M0
    21. XM_047449921.1XP_047305877.1  transmembrane protein 131-like isoform X30

      UniProtKB/TrEMBL
      H0Y2M0
    22. XM_047449923.1XP_047305879.1  transmembrane protein 131-like isoform X32

      UniProtKB/TrEMBL
      H0Y2M0
      Related
      ENSP00000240487.5, ENST00000240487.5
    23. XM_047449925.1XP_047305881.1  transmembrane protein 131-like isoform X34

      UniProtKB/TrEMBL
      H0Y2M0
    24. XM_024453957.2XP_024309725.1  transmembrane protein 131-like isoform X12

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:91174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    25. XM_047449907.1XP_047305863.1  transmembrane protein 131-like isoform X13

      UniProtKB/TrEMBL
      H0Y2M0
    26. XM_017007926.2XP_016863415.1  transmembrane protein 131-like isoform X18

      UniProtKB/TrEMBL
      H0Y2M0
    27. XM_047449922.1XP_047305878.1  transmembrane protein 131-like isoform X31

      UniProtKB/TrEMBL
      H0Y2M0
    28. XM_047449924.1XP_047305880.1  transmembrane protein 131-like isoform X33

      UniProtKB/TrEMBL
      H0Y2M0
    29. XM_047449926.1XP_047305882.1  transmembrane protein 131-like isoform X35

      UniProtKB/TrEMBL
      H0Y2M0
    30. XM_047449911.1XP_047305867.1  transmembrane protein 131-like isoform X19

      UniProtKB/TrEMBL
      H0Y2M0
    31. XM_047449913.1XP_047305869.1  transmembrane protein 131-like isoform X21

      UniProtKB/TrEMBL
      H0Y2M0
    32. XM_047449915.1XP_047305871.1  transmembrane protein 131-like isoform X23

      UniProtKB/TrEMBL
      H0Y2M0
    33. XM_047449927.1XP_047305883.1  transmembrane protein 131-like isoform X36

      UniProtKB/TrEMBL
      H0Y2M0
    34. XM_047449912.1XP_047305868.1  transmembrane protein 131-like isoform X20

      UniProtKB/TrEMBL
      H0Y2M0
    35. XM_047449914.1XP_047305870.1  transmembrane protein 131-like isoform X22

      UniProtKB/TrEMBL
      H0Y2M0
    36. XM_047449916.1XP_047305872.1  transmembrane protein 131-like isoform X24

      UniProtKB/TrEMBL
      H0Y2M0
    37. XM_047449928.1XP_047305884.1  transmembrane protein 131-like isoform X37

      UniProtKB/TrEMBL
      H0Y2M0
    38. XM_047449929.1XP_047305885.1  transmembrane protein 131-like isoform X38

      UniProtKB/TrEMBL
      H0Y2M0
    39. XM_047449930.1XP_047305886.1  transmembrane protein 131-like isoform X39

      UniProtKB/TrEMBL
      H0Y2M0
    40. XM_024453958.2XP_024309726.1  transmembrane protein 131-like isoform X40

      UniProtKB/TrEMBL
      B3KU55

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      156790800..156961149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349416.1XP_054205391.1  transmembrane protein 131-like isoform X1

      UniProtKB/TrEMBL
      H0Y2M0
    2. XM_054349419.1XP_054205394.1  transmembrane protein 131-like isoform X4

      UniProtKB/TrEMBL
      H0Y2M0
    3. XM_054349425.1XP_054205400.1  transmembrane protein 131-like isoform X10

      UniProtKB/TrEMBL
      H0Y2M0
    4. XM_054349426.1XP_054205401.1  transmembrane protein 131-like isoform X11

      UniProtKB/TrEMBL
      H0Y2M0
    5. XM_054349432.1XP_054205407.1  transmembrane protein 131-like isoform X17

      UniProtKB/TrEMBL
      H0Y2M0
    6. XM_054349445.1XP_054205420.1  transmembrane protein 131-like isoform X30

      UniProtKB/TrEMBL
      H0Y2M0
    7. XM_054349447.1XP_054205422.1  transmembrane protein 131-like isoform X32

      UniProtKB/TrEMBL
      H0Y2M0
    8. XM_054349449.1XP_054205424.1  transmembrane protein 131-like isoform X34

      UniProtKB/TrEMBL
      H0Y2M0
    9. XM_054349427.1XP_054205402.1  transmembrane protein 131-like isoform X12

      UniProtKB/TrEMBL
      H0Y2M0
    10. XM_054349428.1XP_054205403.1  transmembrane protein 131-like isoform X13

      UniProtKB/TrEMBL
      H0Y2M0
    11. XM_054349433.1XP_054205408.1  transmembrane protein 131-like isoform X18

      UniProtKB/TrEMBL
      H0Y2M0
    12. XM_054349446.1XP_054205421.1  transmembrane protein 131-like isoform X31

      UniProtKB/TrEMBL
      H0Y2M0
    13. XM_054349448.1XP_054205423.1  transmembrane protein 131-like isoform X33

      UniProtKB/TrEMBL
      H0Y2M0
    14. XM_054349450.1XP_054205425.1  transmembrane protein 131-like isoform X35

      UniProtKB/TrEMBL
      H0Y2M0
    15. XM_054349434.1XP_054205409.1  transmembrane protein 131-like isoform X19

      UniProtKB/TrEMBL
      H0Y2M0
    16. XM_054349436.1XP_054205411.1  transmembrane protein 131-like isoform X21

      UniProtKB/TrEMBL
      H0Y2M0
    17. XM_054349438.1XP_054205413.1  transmembrane protein 131-like isoform X23

      UniProtKB/TrEMBL
      H0Y2M0
    18. XM_054349451.1XP_054205426.1  transmembrane protein 131-like isoform X36

      UniProtKB/TrEMBL
      H0Y2M0
    19. XM_054349435.1XP_054205410.1  transmembrane protein 131-like isoform X20

      UniProtKB/TrEMBL
      H0Y2M0
    20. XM_054349437.1XP_054205412.1  transmembrane protein 131-like isoform X22

      UniProtKB/TrEMBL
      H0Y2M0
    21. XM_054349439.1XP_054205414.1  transmembrane protein 131-like isoform X24

      UniProtKB/TrEMBL
      H0Y2M0
    22. XM_054349452.1XP_054205427.1  transmembrane protein 131-like isoform X37

      UniProtKB/TrEMBL
      H0Y2M0
    23. XM_054349418.1XP_054205393.1  transmembrane protein 131-like isoform X3

      UniProtKB/TrEMBL
      H0Y2M0
    24. XM_054349421.1XP_054205396.1  transmembrane protein 131-like isoform X6

      UniProtKB/TrEMBL
      H0Y2M0
    25. XM_054349453.1XP_054205428.1  transmembrane protein 131-like isoform X38

      UniProtKB/TrEMBL
      H0Y2M0
    26. XM_054349454.1XP_054205429.1  transmembrane protein 131-like isoform X39

      UniProtKB/TrEMBL
      H0Y2M0
    27. XM_054349440.1XP_054205415.1  transmembrane protein 131-like isoform X25

      UniProtKB/TrEMBL
      H0Y2M0
    28. XM_054349443.1XP_054205418.1  transmembrane protein 131-like isoform X28

      UniProtKB/TrEMBL
      H0Y2M0
    29. XM_054349444.1XP_054205419.1  transmembrane protein 131-like isoform X29

      UniProtKB/TrEMBL
      H0Y2M0
    30. XM_054349420.1XP_054205395.1  transmembrane protein 131-like isoform X5

      UniProtKB/TrEMBL
      H0Y2M0
    31. XM_054349417.1XP_054205392.1  transmembrane protein 131-like isoform X2

      UniProtKB/TrEMBL
      H0Y2M0
    32. XM_054349422.1XP_054205397.1  transmembrane protein 131-like isoform X7

      UniProtKB/TrEMBL
      H0Y2M0
    33. XM_054349441.1XP_054205416.1  transmembrane protein 131-like isoform X26

      UniProtKB/TrEMBL
      H0Y2M0
    34. XM_054349442.1XP_054205417.1  transmembrane protein 131-like isoform X27

      UniProtKB/TrEMBL
      H0Y2M0
    35. XM_054349423.1XP_054205398.1  transmembrane protein 131-like isoform X8

      UniProtKB/TrEMBL
      H0Y2M0
    36. XM_054349429.1XP_054205404.1  transmembrane protein 131-like isoform X14

      UniProtKB/TrEMBL
      H0Y2M0
    37. XM_054349430.1XP_054205405.1  transmembrane protein 131-like isoform X15

      UniProtKB/TrEMBL
      H0Y2M0
    38. XM_054349424.1XP_054205399.1  transmembrane protein 131-like isoform X9

      UniProtKB/TrEMBL
      H0Y2M0
    39. XM_054349431.1XP_054205406.1  transmembrane protein 131-like isoform X16

      UniProtKB/TrEMBL
      H0Y2M0
    40. XM_054349455.1XP_054205430.1  transmembrane protein 131-like isoform X41

      UniProtKB/TrEMBL
      B3KU55