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    OR2AG2 olfactory receptor family 2 subfamily AG member 2 [ Homo sapiens (human) ]

    Gene ID: 338755, updated on 10-Dec-2024

    Summary

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    Official Symbol
    OR2AG2provided by HGNC
    Official Full Name
    olfactory receptor family 2 subfamily AG member 2provided by HGNC
    Primary source
    HGNC:HGNC:15143
    See related
    Ensembl:ENSG00000188124 AllianceGenome:HGNC:15143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR11-76; OR2AG2P
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Orthologs
    all
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    Genomic context

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    See OR2AG2 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6765626..6771976, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6824061..6830411, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6786857..6793207, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene GTPase, very large interferon inducible pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4358 Neighboring gene GTPase, very large interferon inducible pseudogene 2 Neighboring gene olfactory receptor family 2 subfamily AG member 1 Neighboring gene olfactory receptor family 6 subfamily A member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma. Chakraborty S, et al. Sci Rep, 2019 Dec 13. PMID 31836740, Free PMC Article
    2. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
    3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma.
      Title: Genetic variations in olfactory receptor gene OR2AG2 in a large multigenerational family with asthma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 2AG2
    Names
    olfactory receptor OR11-76 pseudogene
    olfactory receptor, family 2, subfamily AG, member 2 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004490.2 → NP_001004490.1  olfactory receptor 2AG2

      See identical proteins and their annotated locations for NP_001004490.1

      Status: VALIDATED

      Source sequence(s)
      AC087280, AC091564
      Consensus CDS
      CCDS31413.1
      UniProtKB/Swiss-Prot
      A6NM03, B9EIM0
      UniProtKB/TrEMBL
      A0A126GW54, A0A126GWC6
      Related
      ENSP00000493362.1, ENST00000641124.1
      Conserved Domains (1) summary
      cd15421
      Location:26 → 301
      7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001386053.1 → NP_001372982.1  olfactory receptor 2AG2

      Status: VALIDATED

      Source sequence(s)
      AC087280, AC091564
      Consensus CDS
      CCDS31413.1
      UniProtKB/Swiss-Prot
      A6NM03, B9EIM0
      UniProtKB/TrEMBL
      A0A126GW54, A0A126GWC6
      Related
      ENSP00000493311.1, ENST00000641169.1
      Conserved Domains (1) summary
      cd15421
      Location:26 → 301
      7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6765626..6771976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6824061..6830411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NM03.1 GenPept UniProtKB/Swiss-Prot:A6NM03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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