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    LINC01559 long intergenic non-protein coding RNA 1559 [ Homo sapiens (human) ]

    Gene ID: 283422, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01559provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1559provided by HGNC
    Primary source
    HGNC:HGNC:26598
    See related
    Ensembl:ENSG00000180861 AllianceGenome:HGNC:26598
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C12orf36
    Expression
    Biased expression in colon (RPKM 13.2), gall bladder (RPKM 8.1) and 3 other tissues See more
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    Genomic context

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    See LINC01559 in Genome Data Viewer
    Location:
    12p13.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (13370671..13376745, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (13245076..13251150, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13523605..13529679, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902882 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:13318180-13319379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6033 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:13336996-13337496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:13337497-13337997 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:13351700-13352200 Neighboring gene epithelial membrane protein 1 Neighboring gene Sharpr-MPRA regulatory region 3500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:13409703-13410569 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:13418011-13418585 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:13417435-13418010 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:13492223-13493422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:13521335-13521834 Neighboring gene NANOG hESC enhancer GRCh37_chr12:13521894-13522420 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:13528282-13529481 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:13591195-13591716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:13591717-13592238 Neighboring gene RNA, 5S ribosomal pseudogene 353 Neighboring gene RNA, U6 small nuclear 590, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA LINC01559 serves as a competing endogenous RNA accelerating triple-negative breast cancer progression. Yang X, et al. Biomed J, 2022 Jun. PMID 35715331, Free PMC Article
    2. FTO-mediated epigenetic upregulation of LINC01559 confers cell resistance to docetaxel in breast carcinoma by suppressing miR-1343-3p. Lin W, et al. Kaohsiung J Med Sci, 2023 Sep. PMID 37584416
    3. Linc01559 Served as a Potential Oncogene and Promoted Resistance of Hepatocellular Carcinoma to Oxaliplatin by Directly Sponging miR-6783-3p. Dong S, et al. Anticancer Agents Med Chem, 2021. PMID 32698745
    4. LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway. Lou C, et al. J Cell Physiol, 2020 Apr. PMID 31608998
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FTO-mediated epigenetic upregulation of LINC01559 confers cell resistance to docetaxel in breast carcinoma by suppressing miR-1343-3p.
      Title: FTO-mediated epigenetic upregulation of LINC01559 confers cell resistance to docetaxel in breast carcinoma by suppressing miR-1343-3p.
    2. Long non-coding RNA LINC01559 serves as a competing endogenous RNA accelerating triple-negative breast cancer progression.
      Title: Long non-coding RNA LINC01559 serves as a competing endogenous RNA accelerating triple-negative breast cancer progression.
    3. Linc01559 Served as a Potential Oncogene and Promoted Resistance of Hepatocellular Carcinoma to Oxaliplatin by Directly Sponging miR-6783-3p.
      Title: Linc01559 Served as a Potential Oncogene and Promoted Resistance of Hepatocellular Carcinoma to Oxaliplatin by Directly Sponging miR-6783-3p.
    4. LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway.
      Title: LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Clone Names

    • FLJ33810, FLJ97127, MGC120140

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_036555.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022276, AK091129, BG421494
      Related
      ENST00000318426.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      13370671..13376745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      13245076..13251150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182558.1: Suppressed sequence

      Description
      NM_182558.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q495D7.1 GenPept UniProtKB/Swiss-Prot:Q495D7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials