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    SYP1 Syp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SYP1
    Official Full Name
    Syp1p
    Primary source
    SGD:S000000626
    Locus tag
    YCR030C
    See related
    AllianceGenome:SGD:S000000626; FungiDB:YCR030C; VEuPathDB:YCR030C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YCR029C-A
    Summary
    Enables enzyme inhibitor activity. Involved in actin cortical patch assembly and septin cytoskeleton organization. Located in several cellular components, including cellular bud neck septin ring; endocytic patch; and mating projection base. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FCHO1 (FCH and mu domain containing endocytic adaptor 1); FCHO2 (FCH and mu domain containing endocytic adaptor 2); and SGIP1 (SH3GL interacting endocytic adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SYP1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (173826..176438, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Fen2p Neighboring gene Rim1p Neighboring gene ncRNA Neighboring gene ribosomal 40S subunit protein S14A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cell-signaling network temporally resolves specific versus promiscuous phosphorylation. Kanshin E, et al. Cell Rep, 2015 Feb 24. PMID 25704821
    2. Neck compartmentalization as the molecular basis for the different endocytic behaviour of Chs3 during budding or hyperpolarized growth in yeast cells. Sacristan C, et al. Mol Microbiol, 2012 Mar. PMID 22295943
    3. The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation. Boettner DR, et al. Curr Biol, 2009 Dec 15. PMID 19962315, Free PMC Article
    4. Early-arriving Syp1p and Ede1p function in endocytic site placement and formation in budding yeast. Stimpson HE, et al. Mol Biol Cell, 2009 Nov. PMID 19776351, Free PMC Article
    5. Membrane-sculpting BAR domains generate stable lipid microdomains. Zhao H, et al. Cell Rep, 2013 Sep 26. PMID 24055060, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast.
      Title: The conserved protein adaptors CALM/AP180 and FCHo1/2 cooperatively recruit Eps15 to promote the initiation of clathrin-mediated endocytosis in yeast.
    2. Syp1 can promote internalization of Ptr2 through a recently identified clathrin-independent endocytic pathway that requires the Rho1 GTPase. These findings elucidate the mechanism of Syp1 cargo recognition and its role in trafficking.
      Title: Syp1 regulates the clathrin-mediated and clathrin-independent endocytosis of multiple cargo proteins through a novel sorting motif.
    3. These data identify Syp1 as a novel negative regulator of WASp-Arp2/3 complex that helps choreograph the precise timing of actin assembly during endocytosis.
      Title: The F-BAR protein Syp1 negatively regulates WASp-Arp2/3 complex activity during endocytic patch formation.
    4. Results suggest that Ede1p and Syp1p are conserved, early-arriving endocytic proteins with roles in the formation and placement of endocytic sites, respectively.
      Title: Early-arriving Syp1p and Ede1p function in endocytic site placement and formation in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cortical patch assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in septin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin cytoskeleton organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mating projection base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    Syp1p
    NP_009959.2
    • Inhibitor of Las17p-mediated Arp2/3 complex activation; F-BAR protein that directly inhibits Las17p stimulation of Arp2/3 complex-mediated actin assembly in vitro; involved in formation of the endocytic site; intrinsically disordered domain induces bundling of Cdc11p-capped septin filaments to promote septin collar assembly, similar to mammalian ortholog FCHo2; localizes to sites of polarized growth, the septin ring, and endocytic patches; involved in actin cytoskeletal organization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      173826..176438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178744.1 → NP_009959.2  TPA: Syp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009959.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR40, P25622, P25623, Q96VH0
      UniProtKB/TrEMBL
      A6ZTL1, B3LUA1, C8Z4C0, N1P9A7
      Conserved Domains (4) summary
      cd07650
      Location:16 → 250
      F-BAR_Syp1p_like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of yeast Syp1 protein
      PHA03247
      Location:409 → 574
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:251 → 530
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam10291
      Location:610 → 867
      muHD; Muniscin C-terminal mu homology domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25623.3

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