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    Vnn3 vanin 3 [ Mus musculus (house mouse) ]

    Gene ID: 26464, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Vnn3provided by MGI
    Official Full Name
    vanin 3provided by MGI
    Primary source
    MGI:MGI:1347055
    See related
    Ensembl:ENSMUSG00000020010 AllianceGenome:MGI:1347055
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables pantetheine hydrolase activity. Involved in pantothenate metabolic process. Located in extracellular space. Is expressed in early conceptus and liver. Orthologous to human VNN3P (vanin 3, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 44.4), liver adult (RPKM 22.2) and 4 other tissues See more
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    Genomic context

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    See Vnn3 in Genome Data Viewer
    Location:
    10 A4; 10 11.24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (23727360..23745741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23851462..23869843)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2931 Neighboring gene predicted gene, 23130 Neighboring gene ribosomal protein S12 Neighboring gene STARR-seq mESC enhancer starr_26049 Neighboring gene solute carrier family 18, subfamily B, member 1 Neighboring gene STARR-seq mESC enhancer starr_26051 Neighboring gene STARR-positive B cell enhancer ABC_E8327 Neighboring gene STARR-seq mESC enhancer starr_26053 Neighboring gene STARR-seq mESC enhancer starr_26055 Neighboring gene vanin 1 Neighboring gene STARR-seq mESC enhancer starr_26056 Neighboring gene trace amine-associated receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. Aurrand-Lions M, et al. Immunity, 1996 Nov. PMID 8934567
    2. Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. Min-Oo G, et al. J Exp Med, 2007 Mar 19. PMID 17312006, Free PMC Article
    3. An ESTs description of the new Vanin gene family conserved from fly to human. Granjeaud S, et al. Immunogenetics, 1999 Oct. PMID 10501839
    4. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Martin F, et al. Immunogenetics, 2001 May-Jun. PMID 11491533
    5. Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation. Karagianni P, et al. Cell Rep, 2020 Feb 4. PMID 32023452, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124285

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables pantetheine hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantetheine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pantothenate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pantothenate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vascular non-inflammatory molecule 3
    NP_036109.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011979.2 → NP_036109.3  vascular non-inflammatory molecule 3 precursor

      See identical proteins and their annotated locations for NP_036109.3

      Status: VALIDATED

      Source sequence(s)
      AC153973
      Consensus CDS
      CCDS23734.1
      UniProtKB/Swiss-Prot
      E9QMT9, Q9QZ25
      UniProtKB/TrEMBL
      Q2T9H5
      Related
      ENSMUSP00000020190.8, ENSMUST00000020190.8
      Conserved Domains (1) summary
      cd07567
      Location:26 → 329
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      23727360..23745741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZ25.3 GenPept UniProtKB/Swiss-Prot:Q9QZ25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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