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    Marchf9 membrane associated ring-CH-type finger 9 [ Mus musculus (house mouse) ]

    Gene ID: 216438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Marchf9provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 9provided by MGI
    Primary source
    MGI:MGI:2446144
    See related
    Ensembl:ENSMUSG00000040502 AllianceGenome:MGI:2446144
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    March9
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in Golgi membrane and lysosomal membrane. Predicted to be active in Golgi stack and trans-Golgi network. Is expressed in cortical plate. Orthologous to human MARCHF9 (membrane associated ring-CH-type finger 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 17.3), CNS E18 (RPKM 15.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Marchf9 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126891919..126896053, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127056050..127060184, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene methyltransferase 1, tRNA methylguanosine Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126500339-126500526 Neighboring gene cyclin dependent kinase 4 Neighboring gene RIKEN cDNA A730063M14 gene Neighboring gene tetraspanin 31 Neighboring gene STARR-positive B cell enhancer ABC_E582

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi stack ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF9
    Names
    E3 ubiquitin-protein ligase MARCH9
    MARCH-IX
    RING-type E3 ubiquitin transferase MARCH9
    RING-type E3 ubiquitin transferase MARCHF9
    membrane-associated RING finger protein 9
    membrane-associated RING-CH protein IX
    membrane-associated ring finger (C3HC4) 9
    NP_001028434.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033262.2 → NP_001028434.1  E3 ubiquitin-protein ligase MARCHF9

      See identical proteins and their annotated locations for NP_001028434.1

      Status: PROVISIONAL

      Source sequence(s)
      AK158026
      Consensus CDS
      CCDS24225.1
      UniProtKB/Swiss-Prot
      Q3TZ87, Q8VCL1
      Related
      ENSMUSP00000041581.6, ENSMUST00000040307.6
      Conserved Domains (1) summary
      smart00744
      Location:109 → 155
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      126891919..126896053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TZ87.1 GenPept UniProtKB/Swiss-Prot:Q3TZ87

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools