Lrrc45 leucine rich repeat containing 45 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc45provided by MGI
Official Full Name: leucine rich repeat containing 45provided by MGI
Primary source: MGI:MGI:2387183
See related: Ensembl:ENSMUSG00000025145 AllianceGenome:MGI:2387183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to be located in cytosol and nucleoplasm. Predicted to be active in centrosome and plasma membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human LRRC45 (leucine rich repeat containing 45). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 25.4), ovary adult (RPKM 22.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.45 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120604779..120611954)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120713888..120721128)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153545.2 → NP_705773.2 leucine-rich repeat-containing protein 45

See identical proteins and their annotated locations for NP_705773.2

Status: VALIDATED

Source sequence(s)

AK153361, CN539620

Consensus CDS

CCDS25753.1

UniProtKB/Swiss-Prot

A2AC12, Q3U5Z2, Q8CIM1

Related

ENSMUSP00000026139.8, ENSMUST00000026139.14

Conserved Domains (3) summary

TIGR02168
Location:267 → 608

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

sd00033
Location:30 → 55

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:35 → 229

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...