Hdac7 histone deacetylase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdac7provided by MGI
Official Full Name: histone deacetylase 7provided by MGI
Primary source: MGI:MGI:1891835
See related: Ensembl:ENSMUSG00000022475 AllianceGenome:MGI:1891835
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HD7; HD7a; Hdac7a; mFLJ00062; 5830434K02Rik
Summary: Enables chromatin binding activity; histone deacetylase activity; and transcription corepressor activity. Acts upstream of or within cell-cell junction assembly; negative regulation of transcription by RNA polymerase II; and vasculogenesis. Is active in nucleus. Is expressed in several structures, including adrenal gland; cerebral cortex; heart; and sensory organ. Orthologous to human HDAC7 (histone deacetylase 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 141.4), lung adult (RPKM 54.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 53.79 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (97690542..97742383, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (97792661..97844502, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.
Title: Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.
SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.
Title: SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation.
Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
Title: Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells.
A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells.
Title: A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells.
HDAC7 Activates IKK/NF-kappaB Signaling to Regulate Astrocyte-Mediated Inflammation.
Title: HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation.
Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
Title: Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2.
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
Title: Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
HDAC7 is a bona fide transcriptional repressor essential for B cell development.
Title: In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development.
In the dorsal hippocampus, HDAC7 expression is decreased following contextual fear conditioning.
Title: HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation.
This study demonstrated that hdac7 decrease in skeletal muscle in muscle atrophy.
Title: Differential expression of HDAC and HAT genes in atrophying skeletal muscle.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_4297-4298:996679522:1 (e-PCR)
- UniSTS:269348

42.MMHAP16FLF6.seq (e-PCR)
- UniSTS:124453

MARC_6513-6514:996689732:1 (e-PCR)
- UniSTS:269667

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	TAS Traceable Author Statement more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K14 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K12 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K5 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone H4K8 deacetylase activity, hydrolytic mechanism	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables tubulin deacetylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell activation	TAS Traceable Author Statement more info	PubMed
involved_in B cell differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell-cell junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	TAS Traceable Author Statement more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of striated muscle tissue development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: histone deacetylase 7

Names: histone deacetylase 7A; protein deacetylase HDAC7

NP_001191204.1

EC 3.5.1.98

NP_001191205.1

EC 3.5.1.98

NP_001191206.1

EC 3.5.1.98

NP_001191207.1

EC 3.5.1.98

NP_001191208.1

EC 3.5.1.98

NP_001191209.1

EC 3.5.1.98

NP_001191210.1

EC 3.5.1.98

NP_001365900.1

EC 3.5.1.98

NP_062518.2

EC 3.5.1.98

XP_006521268.1

EC 3.5.1.98

XP_006521270.1

EC 3.5.1.98

XP_006521271.1

EC 3.5.1.98

XP_006521272.1

EC 3.5.1.98

XP_006521273.1

EC 3.5.1.98

XP_030104529.1

EC 3.5.1.98

XP_036015418.1

EC 3.5.1.98

XP_036015419.1

EC 3.5.1.98

XP_036015420.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204275.1 → NP_001191204.1 histone deacetylase 7 isoform 1

See identical proteins and their annotated locations for NP_001191204.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC158787

Consensus CDS

CCDS57006.1

UniProtKB/TrEMBL

Q6KAT4

Related

ENSMUSP00000112110.3, ENSMUST00000116409.9

Conserved Domains (2) summary

cd10008
Location:522 → 897

HDAC7; Histone deacetylase 7

PHA03247
Location:100 → 503

PHA03247; large tegument protein UL36; Provisional
NM_001204276.1 → NP_001191205.1 histone deacetylase 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC158787

Consensus CDS

CCDS57005.1

UniProtKB/TrEMBL

Q6KAT4

Related

ENSMUSP00000113380.2, ENSMUST00000118294.8

Conserved Domains (1) summary

cd10008
Location:515 → 890

HDAC7; Histone deacetylase 7
NM_001204277.1 → NP_001191206.1 histone deacetylase 7 isoform 3

See identical proteins and their annotated locations for NP_001191206.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK044287, BB648696

Consensus CDS

CCDS57007.1

UniProtKB/TrEMBL

Q6KAT4

Related

ENSMUSP00000078766.8, ENSMUST00000079838.14

Conserved Domains (1) summary

cd10008
Location:513 → 888

HDAC7; Histone deacetylase 7
NM_001204278.1 → NP_001191207.1 histone deacetylase 7 isoform 5

See identical proteins and their annotated locations for NP_001191207.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.

Source sequence(s)

AC158787

Consensus CDS

CCDS57004.1

UniProtKB/TrEMBL

Q6KAT4

Related

ENSMUSP00000112109.3, ENSMUST00000116408.9

Conserved Domains (1) summary

cd10008
Location:485 → 860

HDAC7; Histone deacetylase 7
NM_001204279.1 → NP_001191208.1 histone deacetylase 7 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks a coding exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.

Source sequence(s)

AC158787

Consensus CDS

CCDS57001.1

UniProtKB/TrEMBL

E9PXW1, Q6KAT4

Related

ENSMUSP00000112459.2, ENSMUST00000119670.8

Conserved Domains (1) summary

cd10008
Location:461 → 836

HDAC7; Histone deacetylase 7
NM_001204280.1 → NP_001191209.1 histone deacetylase 7 isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks three exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.

Source sequence(s)

AC158787

Consensus CDS

CCDS57003.1

UniProtKB/TrEMBL

E9PXW8, Q6KAT4

Related

ENSMUSP00000112446.2, ENSMUST00000120683.8

Conserved Domains (1) summary

cl17011
Location:485 → 812

Arginase_HDAC; Arginase-like and histone-like hydrolases
NM_001204281.1 → NP_001191210.1 histone deacetylase 7 isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.

Source sequence(s)

AC158787

Consensus CDS

CCDS57002.1

UniProtKB/TrEMBL

E9PX62, Q6KAT4

Related

ENSMUSP00000112641.2, ENSMUST00000121514.8

Conserved Domains (1) summary

cd10008
Location:420 → 795

HDAC7; Histone deacetylase 7
NM_001378971.1 → NP_001365900.1 histone deacetylase 7 isoform 9

Status: VALIDATED

Source sequence(s)

AC158787

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:544 → 919

HDAC7; Histone deacetylase 7

PHA03247
Location:122 → 525

PHA03247; large tegument protein UL36; Provisional
NM_019572.3 → NP_062518.2 histone deacetylase 7 isoform 4

See identical proteins and their annotated locations for NP_062518.2

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK044287, BB648696, BC057332

Consensus CDS

CCDS37188.1

UniProtKB/Swiss-Prot

Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72

UniProtKB/TrEMBL

Q6KAT4

Related

ENSMUSP00000085744.6, ENSMUST00000088402.12

Conserved Domains (1) summary

cd10008
Location:507 → 882

HDAC7; Histone deacetylase 7

RNA

NR_166212.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC158787

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

97690542..97742383 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159526.1 → XP_036015419.1 histone deacetylase 7 isoform X4

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:500 → 875

HDAC7; Histone deacetylase 7

PHA03247
Location:122 → 499

PHA03247; large tegument protein UL36; Provisional
XM_030248669.2 → XP_030104529.1 histone deacetylase 7 isoform X3

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:511 → 886

HDAC7; Histone deacetylase 7

PHA03247
Location:20 → 492

PHA03247; large tegument protein UL36; Provisional
XM_006521210.4 → XP_006521273.1 histone deacetylase 7 isoform X2

See identical proteins and their annotated locations for XP_006521273.1

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:522 → 897

HDAC7; Histone deacetylase 7

PHA03247
Location:100 → 503

PHA03247; large tegument protein UL36; Provisional
XM_036159527.1 → XP_036015420.1 histone deacetylase 7 isoform X5

UniProtKB/TrEMBL

Q3UJT5

Conserved Domains (1) summary

cd10008
Location:96 → 471

HDAC7; Histone deacetylase 7
XM_006521208.5 → XP_006521271.1 histone deacetylase 7 isoform X2

See identical proteins and their annotated locations for XP_006521271.1

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:522 → 897

HDAC7; Histone deacetylase 7

PHA03247
Location:100 → 503

PHA03247; large tegument protein UL36; Provisional
XM_006521205.3 → XP_006521268.1 histone deacetylase 7 isoform X2

See identical proteins and their annotated locations for XP_006521268.1

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:522 → 897

HDAC7; Histone deacetylase 7

PHA03247
Location:100 → 503

PHA03247; large tegument protein UL36; Provisional
XM_006521209.3 → XP_006521272.1 histone deacetylase 7 isoform X2

See identical proteins and their annotated locations for XP_006521272.1

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:522 → 897

HDAC7; Histone deacetylase 7

PHA03247
Location:100 → 503

PHA03247; large tegument protein UL36; Provisional
XM_006521207.5 → XP_006521270.1 histone deacetylase 7 isoform X2

See identical proteins and their annotated locations for XP_006521270.1

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:522 → 897

HDAC7; Histone deacetylase 7

PHA03247
Location:100 → 503

PHA03247; large tegument protein UL36; Provisional
XM_036159525.1 → XP_036015418.1 histone deacetylase 7 isoform X1

UniProtKB/TrEMBL

Q6KAT4

Conserved Domains (2) summary

cd10008
Location:546 → 921

HDAC7; Histone deacetylase 7

PHA03247
Location:124 → 527

PHA03247; large tegument protein UL36; Provisional