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    Pilrb2 paired immunoglobin-like type 2 receptor beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 545812, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pilrb2provided by MGI
    Official Full Name
    paired immunoglobin-like type 2 receptor beta 2provided by MGI
    Primary source
    MGI:MGI:2450535
    See related
    Ensembl:ENSMUSG00000066682 AllianceGenome:MGI:2450535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG545812
    Summary
    Predicted to enable MHC class I protein binding activity. Predicted to be located in cell periphery and membrane. Orthologous to human PILRA (paired immunoglobin like type 2 receptor alpha) and PILRB (paired immunoglobin like type 2 receptor beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 6.5), liver E18 (RPKM 3.5) and 14 other tissues See more
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    Genomic context

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    See Pilrb2 in Genome Data Viewer
    Location:
    5 G2; 5 76.85 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137864083..137870083, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137865821..137871758, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger, CW type with PWWP domain 1 Neighboring gene STARR-seq mESC enhancer starr_14656 Neighboring gene paired immunoglobin-like type 2 receptor alpha Neighboring gene STARR-seq mESC enhancer starr_14658 Neighboring gene paired immunoglobin-like type 2 receptor beta 1 Neighboring gene predicted gene, 36551 Neighboring gene predicted gene 3103 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. Wilson MD, et al. Physiol Genomics, 2006 Nov 27. PMID 16926269
    2. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    3. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    4. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    5. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    paired immunoglobulin-like type 2 receptor beta-2
    Names
    activating receptor PILR-beta-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024932.2 → NP_001020103.1  paired immunoglobulin-like type 2 receptor beta-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001020103.1

      Status: PROVISIONAL

      Source sequence(s)
      AK036467
      Consensus CDS
      CCDS51676.1
      UniProtKB/Swiss-Prot
      Q2YFS1
      Related
      ENSMUSP00000131233.2, ENSMUST00000164886.2
      Conserved Domains (1) summary
      cl11960
      Location:40 → 134
      Ig; Immunoglobulin domain

    2. NM_001384202.1 → NP_001371131.1  paired immunoglobulin-like type 2 receptor beta-2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC125063
      UniProtKB/TrEMBL
      A0A0G2JF84
      Related
      ENSMUSP00000143064.2, ENSMUST00000196162.5
      Conserved Domains (2) summary
      cd00096
      Location:40 → 44
      Ig; Ig strand A [structural motif]
      cl11960
      Location:40 → 134
      Ig; Immunoglobulin domain

    RNA

    1. NR_169051.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125063

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137864083..137870083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004942542.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2YFS1.1 GenPept UniProtKB/Swiss-Prot:Q2YFS1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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