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    Nars2 asparaginyl-tRNA synthetase 2 (mitochondrial)(putative) [ Mus musculus (house mouse) ]

    Gene ID: 244141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nars2provided by MGI
    Official Full Name
    asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)provided by MGI
    Primary source
    MGI:MGI:2142075
    See related
    Ensembl:ENSMUSG00000018995 AllianceGenome:MGI:2142075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in embryo; extraembryonic component; and primitive endoderm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 2.7), CNS E11.5 (RPKM 2.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nars2 in Genome Data Viewer
    Location:
    7 E1; 7 53.13 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (96600698..96725606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (96950839..97064758)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene teneurin transmembrane protein 4 Neighboring gene STARR-seq mESC enhancer starr_19580 Neighboring gene predicted gene 15413 Neighboring gene STARR-seq mESC enhancer starr_19583 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104099810-104100111 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104119017-104119317 Neighboring gene STARR-seq mESC enhancer starr_19585 Neighboring gene predicted gene, 22226 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104233795-104234096 Neighboring gene STARR-seq mESC enhancer starr_19586 Neighboring gene STARR-seq mESC enhancer starr_19587 Neighboring gene growth factor receptor bound protein 2-associated protein 2 Neighboring gene STARR-seq mESC enhancer starr_19588 Neighboring gene STARR-seq mESC enhancer starr_19589 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104446044-104446345 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104480601-104480902 Neighboring gene ubiquitin specific peptidase 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome. Simon M, et al. PLoS Genet, 2015 Mar. PMID 25807530, Free PMC Article
    2. Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice. Cai Y, et al. BMC Pulm Med, 2015 Jul 16. PMID 26178733, Free PMC Article
    3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In these cells we show that a decrease in oxygen consumption rates (OCR) and electron transport chain (ETC) activity can be rescued by overexpression of wild type NARS2
      Title: Mutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndrome.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC41336

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparaginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparaginyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    asparaginyl-tRNA synthetase
    Names
    asnRS
    asparagine--tRNA ligase
    asparagine--tRNA ligase, mitochondrial
    probable asparagine--tRNA ligase, mitochondrial
    probable asparaginyl-tRNA synthetase, mitochondrial
    NP_705819.3
    XP_006507879.1
    XP_006507880.1
    XP_011240096.1
    XP_017177741.1
    XP_030098442.1
    XP_030098443.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153591.5 → NP_705819.3  asparaginyl-tRNA synthetase precursor

      See identical proteins and their annotated locations for NP_705819.3

      Status: VALIDATED

      Source sequence(s)
      AC074047, AC162370
      Consensus CDS
      CCDS21454.1
      UniProtKB/Swiss-Prot
      Q8BGV0
      UniProtKB/TrEMBL
      Q8BXJ6
      Related
      ENSMUSP00000044937.6, ENSMUST00000044466.12
      Conserved Domains (3) summary
      PRK03932
      Location:27 → 474
      asnC; asparaginyl-tRNA synthetase; Validated
      cd00776
      Location:133 → 473
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04318
      Location:44 → 119
      EcAsnRS_like_N; EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      96600698..96725606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507816.3 → XP_006507879.1  asparaginyl-tRNA synthetase isoform X2

      UniProtKB/TrEMBL
      Q8BXJ6
      Conserved Domains (1) summary
      PRK03932
      Location:27 → 428
      asnC; asparaginyl-tRNA synthetase; Validated

    2. XM_017322252.3 → XP_017177741.1  asparaginyl-tRNA synthetase isoform X1

      UniProtKB/TrEMBL
      Q8BXJ6
      Conserved Domains (1) summary
      PRK03932
      Location:27 → 439
      asnC; asparaginyl-tRNA synthetase; Validated

    3. XM_030242582.2 → XP_030098442.1  asparaginyl-tRNA synthetase isoform X5

      UniProtKB/TrEMBL
      Q8K0W7
      Conserved Domains (1) summary
      PRK03932
      Location:27 → 270
      asnC; asparaginyl-tRNA synthetase; Validated

    4. XM_006507817.5 → XP_006507880.1  asparaginyl-tRNA synthetase isoform X3

      UniProtKB/TrEMBL
      Q8BXJ6
      Conserved Domains (1) summary
      PRK03932
      Location:22 → 411
      asnC; asparaginyl-tRNA synthetase; Validated

    5. XM_030242583.2 → XP_030098443.1  asparaginyl-tRNA synthetase isoform X5

      UniProtKB/TrEMBL
      Q8K0W7
      Conserved Domains (1) summary
      PRK03932
      Location:27 → 270
      asnC; asparaginyl-tRNA synthetase; Validated

    6. XM_011241794.3 → XP_011240096.1  asparaginyl-tRNA synthetase isoform X4

      UniProtKB/TrEMBL
      Q8K0W7
      Conserved Domains (1) summary
      PRK03932
      Location:13 → 280
      asnC; asparaginyl-tRNA synthetase; Validated

    RNA

    1. XR_004934100.1 RNA Sequence

    2. XR_004934102.1 RNA Sequence

    3. XR_378243.3 RNA Sequence

    4. XR_001785554.3 RNA Sequence

    5. XR_001785553.3 RNA Sequence

    6. XR_001785551.3 RNA Sequence

    7. XR_001785550.3 RNA Sequence

    8. XR_001785552.3 RNA Sequence

    9. XR_001785548.3 RNA Sequence

    10. XR_004934101.1 RNA Sequence

    11. XR_001785549.3 RNA Sequence

    12. XR_001785557.3 RNA Sequence

    13. XR_004934103.1 RNA Sequence

    14. XR_001785558.3 RNA Sequence

    15. XR_001785556.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGV0.1 GenPept UniProtKB/Swiss-Prot:Q8BGV0

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