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    Minar1 membrane integral NOTCH2 associated receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 209743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Minar1provided by MGI
    Official Full Name
    membrane integral NOTCH2 associated receptor 1provided by MGI
    Primary source
    MGI:MGI:2667167
    See related
    Ensembl:ENSMUSG00000039313 AllianceGenome:MGI:2667167
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DD1; Kiaa1024
    Summary
    Predicted to be involved in several processes, including negative regulation of TOR signaling; negative regulation of angiogenesis; and negative regulation of protein ubiquitination. Predicted to be active in plasma membrane. Orthologous to human MINAR1 (membrane integral NOTCH2 associated receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Minar1 in Genome Data Viewer
    Location:
    9 E3.1; 9 47.24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (89469261..89505940, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (89587208..89623887, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57551 Neighboring gene STARR-seq mESC enhancer starr_24877 Neighboring gene predicted gene, 47403 Neighboring gene STARR-positive B cell enhancer ABC_E6786 Neighboring gene transmembrane p24 trafficking protein 3 Neighboring gene ankyrin repeat domain 34C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    2. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    major intrinsically disordered Notch2-binding receptor 1
    Names
    ubiquitination and mTOR signaling protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153509.2 → NP_705729.1  major intrinsically disordered Notch2-binding receptor 1

      See identical proteins and their annotated locations for NP_705729.1

      Status: PROVISIONAL

      Source sequence(s)
      AC121793
      Consensus CDS
      CCDS23395.1
      UniProtKB/Swiss-Prot
      Q14CG5, Q69ZS9, Q8K3V7
      UniProtKB/TrEMBL
      A0A087WS88
      Related
      ENSMUSP00000046111.7, ENSMUST00000044491.13
      Conserved Domains (1) summary
      pfam06789
      Location:760 → 912
      UPF0258; Uncharacterized protein family (UPF0258)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      89469261..89505940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154777.1 → XP_036010670.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q14CG5, Q69ZS9, Q8K3V7
      UniProtKB/TrEMBL
      A0A087WS88
      Conserved Domains (1) summary
      pfam06789
      Location:760 → 912
      UPF0258; Uncharacterized protein family (UPF0258)

    2. XM_036154776.1 → XP_036010669.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q14CG5, Q69ZS9, Q8K3V7
      UniProtKB/TrEMBL
      A0A087WS88
      Conserved Domains (1) summary
      pfam06789
      Location:760 → 912
      UPF0258; Uncharacterized protein family (UPF0258)

    3. XM_006510957.5 → XP_006511020.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006511020.1

      UniProtKB/Swiss-Prot
      Q14CG5, Q69ZS9, Q8K3V7
      UniProtKB/TrEMBL
      A0A087WS88
      Conserved Domains (1) summary
      pfam06789
      Location:760 → 912
      UPF0258; Uncharacterized protein family (UPF0258)

    4. XM_017313265.2 → XP_017168754.1  major intrinsically disordered Notch2-binding receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q14CG5, Q69ZS9, Q8K3V7
      UniProtKB/TrEMBL
      A0A087WS88
      Conserved Domains (1) summary
      pfam06789
      Location:760 → 912
      UPF0258; Uncharacterized protein family (UPF0258)

    RNA

    1. XR_379408.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3V7.1 GenPept UniProtKB/Swiss-Prot:Q8K3V7

    Gene LinkOut

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