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    Krt78 keratin 78 [ Mus musculus (house mouse) ]

    Gene ID: 332131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt78provided by MGI
    Official Full Name
    keratin 78provided by MGI
    Primary source
    MGI:MGI:1917529
    See related
    Ensembl:ENSMUSG00000050463 AllianceGenome:MGI:1917529
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kb40; 2310030B04Rik
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Is active in cornified envelope. Orthologous to human KRT78 (keratin 78). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 6.1), lung adult (RPKM 4.9) and 2 other tissues See more
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    Genomic context

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    See Krt78 in Genome Data Viewer
    Location:
    15 F2; 15 57.15 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101854436..101905059, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101946001..101996624, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene keratin 4 Neighboring gene keratin 79 Neighboring gene keratin 8 Neighboring gene predicted gene, 36026

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression. Langbein L, et al. Cell Tissue Res, 2016 Mar. PMID 26340985
    2. TERRA transcripts are bound by a complex array of RNA-binding proteins. López de Silanes I, et al. Nat Commun, 2010 Jun 29. PMID 20975687
    3. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. Kumar V, et al. J Cell Biol, 2015 Dec 7. PMID 26644517, Free PMC Article
    4. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, et al. Eur J Cell Biol, 2004 Feb. PMID 15085952
    5. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. K78 is strongly expressed in the basal and parabasal cell layers with decreasing intensity in the lower suprabasal cells of keratinising and non-keratinising squamous epithelia and keratinocyte cultures.
      Title: Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    keratin Kb40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212487.4 → NP_997652.4  keratin Kb40

      Status: VALIDATED

      Source sequence(s)
      AK146611, BK004080, BY792966
      Consensus CDS
      CCDS49736.1
      UniProtKB/TrEMBL
      E9Q0F0
      Related
      ENSMUSP00000126197.2, ENSMUST00000164932.3
      Conserved Domains (5) summary
      COG0845
      Location:272 → 590
      AcrA; Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms]
      cl21524
      Location:277 → 379
      PRK13923; putative spore coat protein regulator protein YlbO; Provisional
      pfam00038
      Location:104 → 417
      Filament; Intermediate filament protein
      pfam15272
      Location:167 → 314
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam16208
      Location:63 → 101
      Keratin_2_head; Keratin type II head

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101854436..101905059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245680.2 → XP_011243982.1  keratin Kb40 isoform X2

      Conserved Domains (3) summary
      COG0845
      Location:229 → 547
      AcrA; Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms]
      pfam09606
      Location:426 → 721
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam00038
      Location:61 → 374
      Filament; Intermediate filament protein

    2. XM_006521114.4 → XP_006521177.1  keratin Kb40 isoform X1

      Conserved Domains (4) summary
      COG0845
      Location:358 → 676
      AcrA; Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms]
      pfam09606
      Location:555 → 850
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam00038
      Location:190 → 503
      Filament; Intermediate filament protein
      pfam16208
      Location:147 → 187
      Keratin_2_head; Keratin type II head
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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