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    Dcst2 DC-STAMP domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 329702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcst2provided by MGI
    Official Full Name
    DC-STAMP domain containing 2provided by MGI
    Primary source
    MGI:MGI:2685606
    See related
    Ensembl:ENSMUSG00000109293 AllianceGenome:MGI:2685606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm760
    Summary
    Involved in fusion of sperm to egg plasma membrane involved in single fertilization and sperm-egg recognition. Predicted to be located in acrosomal membrane. Orthologous to human DCST2 (DC-STAMP domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 39.0) and mammary gland adult (RPKM 2.0) See more
    Orthologs
    human all
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    Genomic context

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    See Dcst2 in Genome Data Viewer
    Location:
    3 F1; 3 39.09 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89257724..89284950)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89350417..89377643)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ephrin A4 Neighboring gene ADAM metallopeptidase domain 15 Neighboring gene STARR-positive B cell enhancer ABC_E4553 Neighboring gene DC-STAMP domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_08235 Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_08237 Neighboring gene STARR-positive B cell enhancer ABC_E3446 Neighboring gene predicted gene 15417 Neighboring gene lens epithelial protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Noda T, et al. Commun Biol, 2022 Apr 7. PMID 35393517, Free PMC Article
    2. Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion. Inoue N, et al. Elife, 2021 Apr 19. PMID 33871360, Free PMC Article
    3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
      Title: Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm-egg recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    DC-STAMP domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370853.1 → NP_001357782.1  DC-STAMP domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AC171273
      Consensus CDS
      CCDS89657.1
      UniProtKB/Swiss-Prot
      A0A140LIJ0
      Related
      ENSMUSP00000146838.2, ENSMUST00000208216.2
      Conserved Domains (2) summary
      pfam07782
      Location:342 → 532
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:585 → 627
      Rhodanese_C; Rhodanase C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89257724..89284950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319855.1 → XP_017175344.1  DC-STAMP domain-containing protein 2 isoform X7

      Conserved Domains (2) summary
      pfam07782
      Location:218 → 408
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:461 → 503
      Rhodanese_C; Rhodanase C-terminal

    2. XM_017319854.3 → XP_017175343.1  DC-STAMP domain-containing protein 2 isoform X7

      Conserved Domains (2) summary
      pfam07782
      Location:218 → 408
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:461 → 503
      Rhodanese_C; Rhodanase C-terminal

    3. XM_030252652.2 → XP_030108512.1  DC-STAMP domain-containing protein 2 isoform X8

      Conserved Domains (2) summary
      pfam07782
      Location:158 → 348
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:401 → 443
      Rhodanese_C; Rhodanase C-terminal

    4. XM_017319851.2 → XP_017175340.1  DC-STAMP domain-containing protein 2 isoform X4

      Conserved Domains (2) summary
      pfam07782
      Location:342 → 476
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:529 → 571
      Rhodanese_C; Rhodanase C-terminal

    5. XM_017319849.2 → XP_017175338.1  DC-STAMP domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      pfam07782
      Location:320 → 510
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:563 → 605
      Rhodanese_C; Rhodanase C-terminal

    6. XM_017319852.3 → XP_017175341.1  DC-STAMP domain-containing protein 2 isoform X6

      Conserved Domains (2) summary
      pfam07782
      Location:254 → 444
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:497 → 539
      Rhodanese_C; Rhodanase C-terminal

    7. XM_006502511.4 → XP_006502574.1  DC-STAMP domain-containing protein 2 isoform X9

      See identical proteins and their annotated locations for XP_006502574.1

      Conserved Domains (1) summary
      pfam07782
      Location:342 → 438
      DC_STAMP; DC-STAMP-like protein

    8. XM_011240348.3 → XP_011238650.1  DC-STAMP domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011238650.1

      Conserved Domains (2) summary
      pfam07782
      Location:342 → 532
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:585 → 627
      Rhodanese_C; Rhodanase C-terminal

    9. XM_017319850.2 → XP_017175339.1  DC-STAMP domain-containing protein 2 isoform X3

      Conserved Domains (2) summary
      pfam07782
      Location:290 → 480
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:533 → 575
      Rhodanese_C; Rhodanase C-terminal

    10. XM_006502503.4 → XP_006502566.1  DC-STAMP domain-containing protein 2 isoform X5

      See identical proteins and their annotated locations for XP_006502566.1

      Conserved Domains (2) summary
      pfam07782
      Location:342 → 532
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:585 → 627
      Rhodanese_C; Rhodanase C-terminal

    11. XM_030252653.2 → XP_030108513.1  DC-STAMP domain-containing protein 2 isoform X10

      Conserved Domains (2) summary
      pfam07782
      Location:84 → 218
      DC_STAMP; DC-STAMP-like protein
      pfam12368
      Location:271 → 313
      Rhodanese_C; Rhodanase C-terminal

    RNA

    1. XR_004941336.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A140LIJ0.1 GenPept UniProtKB/Swiss-Prot:A0A140LIJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials