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    Ppfibp1 PTPRF interacting protein, binding protein 1 (liprin beta 1) [ Mus musculus (house mouse) ]

    Gene ID: 67533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppfibp1provided by MGI
    Official Full Name
    PTPRF interacting protein, binding protein 1 (liprin beta 1)provided by MGI
    Primary source
    MGI:MGI:1914783
    See related
    Ensembl:ENSMUSG00000016487 AllianceGenome:MGI:1914783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4632409B19Rik
    Summary
    Predicted to be involved in neuromuscular junction development. Predicted to be located in plasma membrane. Predicted to be active in presynaptic active zone. Is expressed in central nervous system; heart; and retina. Orthologous to human PPFIBP1 (PPFIA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.6), limb E14.5 (RPKM 10.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppfibp1 in Genome Data Viewer
    Location:
    6 G3; 6 77.7 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146788107..146933523)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146886609..147032025)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17808 Neighboring gene STARR-seq mESC enhancer starr_17809 Neighboring gene basic helix-loop-helix ARNT like 2 Neighboring gene single-pass membrane protein with coiled-coil domains 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:146842338-146842638 Neighboring gene RIKEN cDNA 1700034J05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146991206-146991315 Neighboring gene predicted gene, 35876 Neighboring gene RAB15 effector protein Neighboring gene mitochondrial ribosomal protein S35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1). Kriajevska M, et al. J Biol Chem, 2002 Feb 15. PMID 11836260
    2. Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Chou SJ, et al. Nat Neurosci, 2009 Nov. PMID 19820705, Free PMC Article
    3. Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Amaniti EM, et al. Cereb Cortex, 2015 Feb. PMID 24014668
    4. Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation. Leone DP, et al. Cereb Cortex, 2017 Feb 1. PMID 26830346, Free PMC Article
    5. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19075228, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. new molecular target of the S100A4 protein, liprin beta1
      Title: Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cortical microtubule organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    liprin-beta-1
    Names
    PTPRF-interacting protein-binding protein 1
    protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170433.1 → NP_001163904.1  liprin-beta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153575, AC156394, BC072603
      Consensus CDS
      CCDS51958.1
      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Related
      ENSMUSP00000107250.3, ENSMUST00000111623.9
      Conserved Domains (8) summary
      cd09563
      Location:614 → 677
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:688 → 750
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:773 → 844
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      smart00454
      Location:614 → 678
      SAM; Sterile alpha motif
      pfam01519
      Location:105 → 156
      DUF16; Protein of unknown function DUF16
      pfam14662
      Location:106 → 314
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      cl21478
      Location:213 → 307
      ATP-synt_B; ATP synthase B/B' CF(0)
      cl23720
      Location:134 → 255
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001355728.1 → NP_001342657.1  liprin-beta-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153575, AC156394
      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:666 → 729
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:740 → 802
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:825 → 896
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:100 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001355729.1 → NP_001342658.1  liprin-beta-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153575, AC156394
      Consensus CDS
      CCDS39715.1
      UniProtKB/Swiss-Prot
      Q69ZN5, Q6GQV3, Q80VB4, Q8C8U0, Q9CUT7
      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:603 → 666
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:677 → 739
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:762 → 833
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 310
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_026221.2 → NP_080497.1  liprin-beta-1 isoform 2

      See identical proteins and their annotated locations for NP_080497.1

      Status: VALIDATED

      Source sequence(s)
      AC153575, AC156394, BC072603
      Consensus CDS
      CCDS39715.1
      UniProtKB/Swiss-Prot
      Q69ZN5, Q6GQV3, Q80VB4, Q8C8U0, Q9CUT7
      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Related
      ENSMUSP00000016631.8, ENSMUST00000016631.14
      Conserved Domains (4) summary
      cd09563
      Location:603 → 666
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:677 → 739
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:762 → 833
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      cl25732
      Location:47 → 310
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      146788107..146933523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241625.2 → XP_011239927.1  liprin-beta-1 isoform X1

      See identical proteins and their annotated locations for XP_011239927.1

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:666 → 729
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:740 → 802
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:825 → 896
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:100 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_011241624.2 → XP_011239926.1  liprin-beta-1 isoform X1

      See identical proteins and their annotated locations for XP_011239926.1

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:666 → 729
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:740 → 802
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:825 → 896
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:100 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_006507098.4 → XP_006507161.1  liprin-beta-1 isoform X4

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:655 → 718
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:729 → 791
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:814 → 885
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:100 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_006507096.3 → XP_006507159.1  liprin-beta-1 isoform X2

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:656 → 719
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:730 → 792
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:815 → 886
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:100 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_011241627.2 → XP_011239929.1  liprin-beta-1 isoform X5

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:645 → 708
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:719 → 781
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:804 → 875
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:100 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_006507097.3 → XP_006507160.1  liprin-beta-1 isoform X3

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:655 → 718
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:729 → 791
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:814 → 885
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006507101.3 → XP_006507164.1  liprin-beta-1 isoform X13

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:644 → 707
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:718 → 780
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:803 → 874
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_006507099.3 → XP_006507162.1  liprin-beta-1 isoform X6

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:645 → 708
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:719 → 781
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:804 → 875
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    9. XM_036152273.1 → XP_036008166.1  liprin-beta-1 isoform X8

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:634 → 697
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:708 → 770
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:793 → 864
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    10. XM_006507102.3 → XP_006507165.1  liprin-beta-1 isoform X7

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:635 → 698
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:709 → 771
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:794 → 865
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 321
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_036152275.1 → XP_036008168.1  liprin-beta-1 isoform X10

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:624 → 687
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:698 → 760
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:783 → 854
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 321
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. XM_006507103.3 → XP_006507166.1  liprin-beta-1 isoform X9

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:624 → 687
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:698 → 760
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:783 → 854
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 310
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    13. XM_011241629.2 → XP_011239931.1  liprin-beta-1 isoform X12

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:613 → 676
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:687 → 749
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:772 → 843
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 310
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    14. XM_011241628.2 → XP_011239930.1  liprin-beta-1 isoform X11

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:614 → 677
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:688 → 750
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:773 → 844
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 310
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    15. XM_036152272.1 → XP_036008165.1  liprin-beta-1 isoform X4

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:655 → 718
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:729 → 791
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:814 → 885
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:100 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    16. XM_036152274.1 → XP_036008167.1  liprin-beta-1 isoform X8

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:634 → 697
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:708 → 770
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:793 → 864
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 341
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    17. XM_030255565.1 → XP_030111425.1  liprin-beta-1 isoform X7

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:635 → 698
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:709 → 771
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:794 → 865
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:47 → 321
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    18. XM_011241626.3 → XP_011239928.1  liprin-beta-1 isoform X1

      See identical proteins and their annotated locations for XP_011239928.1

      UniProtKB/TrEMBL
      Q3U417, Q3UJ84
      Conserved Domains (4) summary
      cd09563
      Location:666 → 729
      SAM_liprin-beta1,2_repeat1; SAM domain of liprin-beta1,2 proteins repeat 1
      cd09566
      Location:740 → 802
      SAM_liprin-beta1,2_repeat2; SAM domain of liprin-beta1,2 proteins repeat 2
      cd09569
      Location:825 → 896
      SAM_liprin-beta1,2_repeat3; SAM domain of liprin-beta proteins repeat 3
      COG1196
      Location:100 → 378
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C8U0.3 GenPept UniProtKB/Swiss-Prot:Q8C8U0

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