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    Sf3a2 splicing factor 3a, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 20222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sf3a2provided by MGI
    Official Full Name
    splicing factor 3a, subunit 2provided by MGI
    Primary source
    MGI:MGI:104912
    See related
    Ensembl:ENSMUSG00000020211 AllianceGenome:MGI:104912
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    66kDa; PRP11; SFA66; Sap62
    Summary
    Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in U2-type prespliceosome assembly and positive regulation of neuron projection development. Predicted to act upstream of or within RNA splicing, via transesterification reactions. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human SF3A2 (splicing factor 3a subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 42.2), ovary adult (RPKM 32.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sf3a2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80634569..80640756)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80798735..80804922)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DOT1 like histone lysine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_27297 Neighboring gene VISTA enhancer mm200 Neighboring gene pleckstrin homology domain containing, family J member 1 Neighboring gene Amh promoter region Neighboring gene anti-Mullerian hormone Neighboring gene junctional sarcoplasmic reticulum protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Swain A, et al. Nat Genet, 1996 Apr. PMID 8630494
    2. Transcriptional analysis of the candidate spermatogenesis gene Ube1y and of the closely related Ube1x shows that they are coexpressed in spermatogonia and spermatids but are repressed in pachytene spermatocytes. Odorisio T, et al. Dev Biol, 1996 Nov 25. PMID 8948595
    3. An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. Dresser DW, et al. Gene, 2001 Oct 17. PMID 11602354
    4. A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions. Maitra R, et al. Nucleic Acids Res, 2009 Jun. PMID 19324890, Free PMC Article
    5. The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous. Dresser DW, et al. Hum Mol Genet, 1995 Sep. PMID 8541848

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing, via transesterification reactions TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in U2-type prespliceosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in U2-type prespliceosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 3A subunit 2
    Names
    SAP 62
    SF3a66
    spliceosomal protein gene 62
    spliceosome-associated protein 62
    splicing factor 3a, subunit 2, 66kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013651.4 → NP_038679.3  splicing factor 3A subunit 2

      See identical proteins and their annotated locations for NP_038679.3

      Status: VALIDATED

      Source sequence(s)
      BC052697, CX212776, CX214888
      Consensus CDS
      CCDS35986.2
      UniProtKB/TrEMBL
      G3UVU2
      Related
      ENSMUSP00000117160.2, ENSMUST00000148665.8
      Conserved Domains (2) summary
      COG5246
      Location:1 → 217
      PRP11; Splicing factor 3a, subunit 2 [RNA processing and modification]
      cl26386
      Location:324 → 449
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80634569..80640756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62203.2 GenPept UniProtKB/Swiss-Prot:Q62203

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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