Insm2 insulinoma-associated 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Insm2provided by MGI
Official Full Name: insulinoma-associated 2provided by MGI
Primary source: MGI:MGI:1930787
See related: Ensembl:ENSMUSG00000045440 AllianceGenome:MGI:1930787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mlt1
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and pancreas. Orthologous to human INSM2 (INSM transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 24.05 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (55646212..55648818)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (55598917..55602018)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insm2 deficiency results in female infertility by disturbing steroid pathway and decreasing ovarian reserve in mice.
Title: Insm2 deficiency results in female infertility by disturbing steroid pathway and decreasing ovarian reserve in mice.
Insm2 is important in glucose-stimulated insulin secretion.
Title: Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance.
Data suggest that IA-2 and IA-2beta play important roles in regulation of circadian rhythms, likely through their participation in neurochemical communication among neurons of suprachiasmatic nucleus.
Title: Disruption of gene expression rhythms in mice lacking secretory vesicle proteins IA-2 and IA-2β.
Results suggest that Insm2 plays an important role in the differentiation cascade of Ngn3/NeuroD1 signaling in pancreatic islets.
Title: Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

General gene information

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Markers

BB392842 (e-PCR)
- UniSTS:208805

NoName (e-PCR)
- UniSTS:487867

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of transcription repressor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulinoma-associated protein 2

Names: methylated in liver tumor 1; mlt 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020287.3 → NP_064683.2 insulinoma-associated protein 2

See identical proteins and their annotated locations for NP_064683.2

Status: VALIDATED

Source sequence(s)

AC158398

Consensus CDS

CCDS25919.1

UniProtKB/Swiss-Prot

E9QNA9, Q9JMC2

Related

ENSMUSP00000061046.4, ENSMUST00000051857.5

Conserved Domains (3) summary

sd00017
Location:205 → 225

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:354 → 376

zf-C2H2; Zinc finger, C2H2 type

cl26464
Location:2 → 343

Atrophin-1; Atrophin-1 family