U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sycp2l synaptonemal complex protein 2-like [ Mus musculus (house mouse) ]

    Gene ID: 637277, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sycp2lprovided by MGI
    Official Full Name
    synaptonemal complex protein 2-likeprovided by MGI
    Primary source
    MGI:MGI:2685114
    See related
    Ensembl:ENSMUSG00000038651 AllianceGenome:MGI:2685114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm268; Gm40956; EG621792
    Summary
    Acts upstream of or within negative regulation of programmed cell death. Located in condensed chromosome, centromeric region; female germ cell nucleus; and lateral element. Is expressed in ovary. Orthologous to human SYCP2L (synaptonemal complex protein 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sycp2l in Genome Data Viewer
    Location:
    13 A3.3; 13 20.32 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41267895..41327827)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41114419..41174351)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene male germ cell-associated kinase Neighboring gene glial cells missing homolog 2 Neighboring gene STARR-seq mESC enhancer starr_34300 Neighboring gene ELOVL fatty acid elongase 2 Neighboring gene ribosomal protein S17, pseudogene 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Zhou J, et al. Hum Mol Genet, 2015 Nov 15. PMID 26362258, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within menopause IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in condensed chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lateral element IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    synaptonemal complex protein 2-like
    Names
    SCP-2-like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324525.1 → NP_001311454.1  synaptonemal complex protein 2-like

      Status: PROVISIONAL

      Source sequence(s)
      KP872825
      Consensus CDS
      CCDS88444.1
      UniProtKB/Swiss-Prot
      A0A0M3U1B0, D3YWV8, F6RWL8, F6ZC70
      Related
      ENSMUSP00000115127.3, ENSMUST00000124093.3
      Conserved Domains (1) summary
      cl26761
      Location:447 → 558
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      41267895..41327827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0M3U1B0.1 GenPept UniProtKB/Swiss-Prot:A0A0M3U1B0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials