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    LHP1 Lhp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LHP1
    Official Full Name
    Lhp1p
    Primary source
    SGD:S000002209
    Locus tag
    YDL051W
    See related
    AllianceGenome:SGD:S000002209; FungiDB:YDL051W; VEuPathDB:YDL051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LAH1; YLA1
    Summary
    Enables tRNA binding activity. Involved in tRNA processing. Located in nucleolus and nucleoplasm. Orthologous to human SSB (small RNA binding exonuclease protection factor La). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LHP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (363952..364779)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pbp4p Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Neighboring gene Knh1p Neighboring gene Stp4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A yeast RNA binding protein that resembles the human autoantigen La. Lin-Marq N, et al. J Mol Biol, 1995 Jan 13. PMID 7799435
    2. The yeast La protein is required for the 3' endonucleolytic cleavage that matures tRNA precursors. Yoo CJ, et al. Cell, 1997 May 2. PMID 9150139
    3. Phosphorylation of the Saccharomyces cerevisiae La protein does not appear to be required for its functions in tRNA maturation and nascent RNA stabilization. Long KS, et al. RNA, 2001 Nov. PMID 11720288, Free PMC Article
    4. Identification of Lhp1p-associated RNAs by microarray analysis in Saccharomyces cerevisiae reveals association with coding and noncoding RNAs. Inada M, et al. Proc Natl Acad Sci U S A, 2004 Jan 13. PMID 14704279, Free PMC Article
    5. Visual analysis of the yeast 5S rRNA gene transcriptome: regulation and role of La protein. French SL, et al. Mol Cell Biol, 2008 Jul. PMID 18474615, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the C terminus of Lhp1p, although hypersensitive to proteases in vitro, becomes protease-resistant upon binding pre-tRNAs, U6 RNA, or pre-5S rRNA.
      Title: An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors.
    2. The yeast La protein, Lhp1, was associated with 5S genes; its absence had no effect on the amount or size of 5S RNA produced yet resulted in more polymerases per gene on average, consistent with a non-rate-limiting role for Lhp1.
      Title: Visual analysis of the yeast 5S rRNA gene transcriptome: regulation and role of La protein.
    3. Overexpression of the La protein Lhp1p reduces both exonucleolytic pre-tRNA trimming in wild-type cells and the accumulation of defective RNAs in trf4Delta cells.
      Title: Competition between the Rex1 exonuclease and the La protein affects both Trf4p-mediated RNA quality control and pre-tRNA maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lhp1p
    NP_010232.1
    • RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      363952..364779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180110.1 → NP_010232.1  TPA: Lhp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010232.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRU5, P33399
      UniProtKB/TrEMBL
      A6ZXS4, B3LGU9, B5VFL6, C7GW88, C8Z4L8, N1P492
      Conserved Domains (1) summary
      COG5193
      Location:1 → 244
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33399.2

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