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    RGD2 GTPase-activating protein RGD2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RGD2
    Official Full Name
    GTPase-activating protein RGD2
    Primary source
    SGD:S000001847
    Locus tag
    YFL047W
    See related
    AllianceGenome:SGD:S000001847; FungiDB:YFL047W; VEuPathDB:YFL047W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in small GTPase-mediated signal transduction. Located in cellular bud neck; cellular bud tip; and cytoplasm. Human ortholog(s) of this gene implicated in PAPA syndrome and primary immunodeficiency disease. Orthologous to several human genes including FCHO1 (FCH and mu domain containing endocytic adaptor 1); FCHO2 (FCH and mu domain containing endocytic adaptor 2); and SGIP1 (SH3GL interacting endocytic adaptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RGD2 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (40421..42565)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Swp82p Neighboring gene Emp47p Neighboring gene Fmp32p Neighboring gene phosphomannomutase SEC53

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. Roumanie O, et al. FEBS Lett, 2001 Oct 5. PMID 11591390
    2. Differential Requirement for the Cell Wall Integrity Sensor Wsc1p in Diploids Versus Haploids. Hall AE, et al. J Fungi (Basel), 2021 Dec 8. PMID 34947031, Free PMC Article
    3. Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination. Annan RB, et al. Eukaryot Cell, 2008 Sep. PMID 18621925, Free PMC Article
    4. New Aspects of Invasive Growth Regulation Identified by Functional Profiling of MAPK Pathway Targets in Saccharomyces cerevisiae. Vandermeulen MD, et al. Genetics, 2020 Sep. PMID 32665277, Free PMC Article
    5. Cdc24 interacts with septins to create a positive feedback loop during bud site assembly in yeast. Chollet J, et al. J Cell Sci, 2020 Jun 11. PMID 32327559

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in division septum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein RGD2
    NP_428268.1
    • GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      40421..42565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179920.1 → NP_428268.1  TPA: GTPase-activating protein RGD2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_428268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTI3, P43556
      UniProtKB/TrEMBL
      G2WD94, N1P4T5
      Conserved Domains (3) summary
      smart00055
      Location:6 → 96
      FCH; Fes/CIP4 homology domain
      cd04399
      Location:473 → 708
      RhoGAP_fRGD2; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
      cd04436
      Location:205 → 289
      DEP_fRgd2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGAP (GTPase-activator protein) Rgd2-like proteins. Rgd2-like proteins share a common domain architecture, containing, beside the RhoGAP domain, a DEP and a FCH (Fes/CIP4 homology) domain. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43556.1

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