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    LSB1 Lsb1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853037, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSB1
    Official Full Name
    Lsb1p
    Primary source
    SGD:S000003368
    Locus tag
    YGR136W
    See related
    AllianceGenome:SGD:S000003368; FungiDB:YGR136W; VEuPathDB:YGR136W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in negative regulation of Arp2/3 complex-mediated actin nucleation. Located in actin cortical patch. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LSB1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (762428..763153)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core subunit CAF130 Neighboring gene proteasome core particle subunit alpha 3 Neighboring gene spermine transporter Neighboring gene Cbf2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis. Spiess M, et al. PLoS One, 2013. PMID 23577202, Free PMC Article
    2. Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro. Kaminska J, et al. Eur J Cell Biol, 2011 Dec. PMID 22000681
    3. The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins. Körner C, et al. Cell Rep, 2024 Aug 27. PMID 39167489
    4. Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton. Chernova TA, et al. Mol Cell, 2011 Jul 22. PMID 21777813, Free PMC Article
    5. Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion. Ali M, et al. J Biol Chem, 2014 Oct 3. PMID 25143386, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lsb1 is crucial for prion maintenance during stress.
      Title: Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.
    2. Lsb1 and/or Lsb2 full-length proteins inhibit Las17-mediated actin polymerization
      Title: Lsb1 is a negative regulator of las17 dependent actin polymerization involved in endocytosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lsb1p
    NP_011652.1
    • Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      762428..763153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181265.1 → NP_011652.1  TPA: Lsb1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011652.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUR8, P53281
      UniProtKB/TrEMBL
      A6ZUF0, B3LI92, C7GUF9, C8Z929, G2WEL8, N1P433
      Conserved Domains (2) summary
      smart00326
      Location:55 → 108
      SH3; Src homology 3 domains
      PRK14971
      Location:100 → 156
      PRK14971; DNA polymerase III subunit gamma/tau
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53281.1

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