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    Krt28 keratin 28 [ Mus musculus (house mouse) ]

    Gene ID: 70843, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Krt28provided by MGI
    Official Full Name
    keratin 28provided by MGI
    Primary source
    MGI:MGI:1918093
    See related
    Ensembl:ENSMUSG00000055937 AllianceGenome:MGI:1918093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K28; K25D; CK-28; Krt25d; 4733401L19Rik
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation; hair follicle morphogenesis; and intermediate filament organization. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in cytoskeleton. Is expressed in vibrissa. Orthologous to human KRT28 (keratin 28). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Krt28 in Genome Data Viewer
    Location:
    11 D; 11 62.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99255697..99270701, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99365007..99374903, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 26 Neighboring gene keratin 27 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247019-99247320 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247331-99247631 Neighboring gene keratin 10 Neighboring gene RIKEN cDNA A830036E02 gene Neighboring gene keratin 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. Tanaka S, et al. Genomics, 2007 Dec. PMID 17920809
    2. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Fleger-Weckmann A, et al. Matrix Biol, 2016 Dec. PMID 27234308
    3. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Chen A, et al. Cell, 2022 May 12. PMID 35512705
    4. New consensus nomenclature for mammalian keratins. Schweizer J, et al. J Cell Biol, 2006 Jul 17. PMID 16831889, Free PMC Article
    5. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hair follicle morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 28
    Names
    cytokeratin-28
    keratin 25D
    type I inner root sheath-specific keratin-K25irs4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027574.2 → NP_081850.1  keratin, type I cytoskeletal 28

      See identical proteins and their annotated locations for NP_081850.1

      Status: VALIDATED

      Source sequence(s)
      AL591165
      Consensus CDS
      CCDS48906.1
      UniProtKB/Swiss-Prot
      A6BLY7, Q9D637
      Related
      ENSMUSP00000006963.2, ENSMUST00000006963.3
      Conserved Domains (1) summary
      pfam00038
      Location:83 → 397
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99255697..99270701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156988.1 → XP_036012881.1  keratin, type I cytoskeletal 28 isoform X1

      UniProtKB/Swiss-Prot
      A6BLY7, Q9D637
      Conserved Domains (1) summary
      pfam00038
      Location:83 → 397
      Filament; Intermediate filament protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6BLY7.1 GenPept UniProtKB/Swiss-Prot:A6BLY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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