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    Coasy Coenzyme A synthase [ Mus musculus (house mouse) ]

    Gene ID: 71743, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Coasyprovided by MGI
    Official Full Name
    Coenzyme A synthaseprovided by MGI
    Primary source
    MGI:MGI:1918993
    See related
    Ensembl:ENSMUSG00000001755 AllianceGenome:MGI:1918993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dpck; Ppat; Ukr1; 1300003G02Rik
    Summary
    This gene encodes the bifunctional protein coenzyme A (CoA) synthase which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this protein catalyzes the conversion of phosphopantetheine into dephospho-CoA while its dephospho-CoA kinase domain completes the final step by phosphorylating dephospho-CoA to form CoA. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 70.2), liver adult (RPKM 63.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coasy in Genome Data Viewer
    Location:
    11 D; 11 64.17 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100973391..100977445)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101082565..101086619)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8456 Neighboring gene alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100943626-100943809 Neighboring gene STARR-positive B cell enhancer ABC_E7065 Neighboring gene MAX-like protein X Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E11773 Neighboring gene reticulophagy regulator family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CoA synthase plays a critical role in neurodevelopment and neurodegeneration. Cavestro C, et al. Front Cell Neurosci, 2024. PMID 39301217, Free PMC Article
    2. Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model. Di Meo I, et al. Int J Mol Sci, 2020 Dec 19. PMID 33352696, Free PMC Article
    3. Subcellular localization and regulation of coenzyme A synthase. Zhyvoloup A, et al. J Biol Chem, 2003 Dec 12. PMID 14514684
    4. Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis. Zhyvoloup A, et al. J Biol Chem, 2002 Jun 21. PMID 11980892
    5. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). Aghajanian S, et al. Biochem J, 2002 Jul 1. PMID 11994049, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model.
      Title: Neuronal Ablation of CoA Synthase Causes Motor Deficits, Iron Dyshomeostasis, and Mitochondrial Dysfunctions in a CoPAN Mouse Model.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dephospho-CoA kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dephospho-CoA kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables pantetheine-phosphate adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantetheine-phosphate adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pantetheine-phosphate adenylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pantetheine-phosphate adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in purine nucleoside bisphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribonucleoside bisphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional coenzyme A synthase
    Names
    4'-phosphopantetheine adenylyltransferase and dephospho-CoA kinase
    CoA synthase
    NP_001292911.1
    XP_006534319.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305982.1 → NP_001292911.1  bifunctional coenzyme A synthase precursor

      See identical proteins and their annotated locations for NP_001292911.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AK004878, AK159405, BB872569, BC064753
      Consensus CDS
      CCDS25446.1
      UniProtKB/Swiss-Prot
      A2BFA8, Q3TVZ2, Q8K3Y4, Q9DBL7
      Related
      ENSMUSP00000001806.4, ENSMUST00000001806.10
      Conserved Domains (3) summary
      cd02164
      Location:192 → 338
      PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
      COG0237
      Location:358 → 557
      CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
      cd02022
      Location:359 → 535
      DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

    RNA

    1. NR_155015.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. . This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria
      Source sequence(s)
      BX255926

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100973391..100977445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534256.2 → XP_006534319.1  bifunctional coenzyme A synthase isoform X1

      Conserved Domains (2) summary
      cd02022
      Location:133 → 309
      DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
      cl00015
      Location:5 → 112
      nt_trans; nucleotidyl transferase superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027896.4: Suppressed sequence

      Description
      NM_027896.4: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBL7.2 GenPept UniProtKB/Swiss-Prot:Q9DBL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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