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    NIS1 Nis1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NIS1
    Official Full Name
    Nis1p
    Primary source
    SGD:S000005022
    Locus tag
    YNL078W
    See related
    AllianceGenome:SGD:S000005022; FungiDB:YNL078W; VEuPathDB:YNL078W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    JIP1
    Summary
    Predicted to enable SUMO binding activity. Involved in axial cellular bud site selection; establishment of protein localization; and mitotic nuclear division. Located in cellular bud scar; cleavage apparatus septin structure; and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NIS1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (479768..480991)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Eos1p Neighboring gene tropomyosin TPM1 Neighboring gene Apj1p Neighboring gene Mks1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast. Reiter A, et al. EMBO J, 2012 Aug 15. PMID 22805593, Free PMC Article
    2. Molecular evolution of minisatellites in hemiascomycetous yeasts. Richard GF, et al. Mol Biol Evol, 2006 Jan. PMID 16177231
    3. Fine-tuning the orientation of the polarity axis by Rga1, a Cdc42 GTPase-activating protein. Miller KE, et al. Mol Biol Cell, 2017 Dec 15. PMID 29074565, Free PMC Article
    4. The septin-associated kinase Gin4 recruits Gps1 to the site of cell division. Meitinger F, et al. Mol Biol Cell, 2017 Apr 1. PMID 28148650, Free PMC Article
    5. Nis1 encoded by YNL078W: a new neck protein of Saccharomyces cerevisiae. Iwase M, et al. Genes Genet Syst, 2001 Oct. PMID 11817649

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SUMO binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axial cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic nuclear division IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck septin collar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck split septin rings IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nis1p
    NP_014321.3
    • Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited with Nba1p to the cell cortex and to cytokinesis remnants (bud scars) by Aim44p and Nap1p where Nba1p prevents Rsr1p-mediated activation of Cdc24p, and therefore Cdc42p activation; acts with Nba1p to establish transient bud scar localization of Rga1p, a Cdc42p GAP; localizes to the nucleus and to cell division site during G2/M, and is then stably recruited to cytokinesis remnants

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      479768..480991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182916.3 → NP_014321.3  TPA: Nis1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014321.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1A1, P53939
      UniProtKB/TrEMBL
      B3LNT7, B5VQW5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53939.1

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