BEM4 Bem4p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: BEM4
Official Full Name: Bem4p
Primary source: SGD:S000006082
Locus tag: YPL161C
See related: AllianceGenome:SGD:S000006082; FungiDB:YPL161C; VEuPathDB:YPL161C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ROM7
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in Rho protein signal transduction and establishment of cell polarity. Located in cytoplasm and nucleus. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Functions for Cdc42p BEM adaptors in regulating a differentiation-type MAP kinase pathway.
Title: Functions for Cdc42p BEM adaptors in regulating a differentiation-type MAP kinase pathway.
results indicate that BEM4 would be useful to produce therapeutic proteins in glycoengineered yeast without the growth defect
Title: PiggyBac-based screening identified BEM4 as a suppressor to rescue growth defects in och1-disrupted yeast cells.
Bem4p is a new regulator of the filamentous-growth MAPK pathway and binds to general proteins, like Cdc42p
Title: Cdc42p-interacting protein Bem4p regulates the filamentous-growth mitogen-activated protein kinase pathway.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_015164.1

Protein involved in establishment of cell polarity and bud emergence; regulates filamentous-growth mitogen-activated protein kinase (MAPK) pathway; interacts with the Rho1p small GTP-binding protein, the pleckstrin homology (PH) domain of Cdc24p, and with the Rho-type GTPase Cdc42p; stabilizes Cdc42p levels, resulting in elevated fMAPK pathway signaling; involved in maintenance of proper telomere length