Myh4 myosin, heavy polypeptide 4, skeletal muscle [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myh4provided by MGI
Official Full Name: myosin, heavy polypeptide 4, skeletal muscleprovided by MGI
Primary source: MGI:MGI:1339713
See related: Ensembl:ENSMUSG00000057003 AllianceGenome:MGI:1339713
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MM; MHC2B; Myhsf; MYH-2B; Minmus; Minimsc; MyHC-IIb
Summary: Predicted to enable actin filament binding activity; double-stranded RNA binding activity; and microfilament motor activity. Acts upstream of or within response to muscle activity. Predicted to be located in myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including brown fat; heart; limb segment; paraxial mesenchyme; and skeletal musculature. Orthologous to human MYH4 (myosin heavy chain 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward mammary gland adult (RPKM 118.7) See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 40.59 cM

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (67128638..67151273)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (67237812..67260447)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-to-T SNP in a 708-bp intron is responsible for the mini-muscle phenotype, Myh4Minimsc.
Title: A novel intronic single nucleotide polymorphism in the myosin heavy polypeptide 4 gene is responsible for the mini-muscle phenotype characterized by major reduction in hind-limb muscle mass in mice.
A detailed functional study of muscle fibers from Myh4(arl) mice, which carry a mutation that provokes an L342Q change within the catalytic domain of the type IIb skeletal muscle myosin protein MYH4, is reported.
Title: The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q.
study describes the identification of a recessive missense mutation in the Myh4 gene and its consequences at cellular, physiological and pathological level in the ariel mouse; findings suggest that ariel suffers from a fulminant myofibrillar myopathy
Title: Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb.
MHC2B, together with myosin light chain phosphorylation and actin, constitute the actomyosin cytoskeleton that mediates contractility during apoptosis.
Title: Isoform B of myosin II heavy chain mediates actomyosin contractility during TNFalpha-induced apoptosis.
In myotonic fast muscles, hyperexcitability leads to a drastic reduction of MyHC IIB which is compensated by IIA. MyHC pattern of of spinal muscular atrophy (SMA) 'wobbler' mice is shifted to a faster phenotype, with nearly 90% IIB
Title: Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1) 1 citation
QTL (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI506973 (e-PCR)
- UniSTS:185887

Myh1 (e-PCR), detects polymorphism
- UniSTS:143949

Myh13 (e-PCR), detects polymorphism
- UniSTS:143955

UniSTS:265579 (e-PCR)
- UniSTS:265579

Myh4 (e-PCR), detects polymorphism
- UniSTS:265579

433B7T7 (e-PCR), detects polymorphism
- UniSTS:140952

Myh4 (e-PCR), detects polymorphism
- UniSTS:530875

Myh4 (e-PCR), detects polymorphism
- UniSTS:257231

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to muscle activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in myofibril	IEA Inferred from Electronic Annotation more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin-4

Names: myHC-2b; myosin heavy chain 2b; myosin heavy chain 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010855.3 → NP_034985.2 myosin-4

See identical proteins and their annotated locations for NP_034985.2

Status: VALIDATED

Source sequence(s)

AK138608, AL596129

Consensus CDS

CCDS24856.1

UniProtKB/Swiss-Prot

B9EJ73, Q5SX39

UniProtKB/TrEMBL

B2RWX0

Related

ENSMUSP00000018632.5, ENSMUST00000018632.11

Conserved Domains (3) summary

cd14915
Location:100 → 770

MYSc_Myh4; class II myosin heavy chain 4, motor domain

pfam02736
Location:35 → 73

Myosin_N; Myosin N-terminal SH3-like domain

cl25732
Location:850 → 1927

SMC_N; RecF/RecN/SMC N terminal domain