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    Rragd Ras-related GTP binding D [ Mus musculus (house mouse) ]

    Gene ID: 52187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rragdprovided by MGI
    Official Full Name
    Ras-related GTP binding Dprovided by MGI
    Primary source
    MGI:MGI:1098604
    See related
    Ensembl:ENSMUSG00000028278 AllianceGenome:MGI:1098604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4Ertd174e; 5730543C08Rik; C030003H22Rik
    Summary
    Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and positive regulation of TORC1 signaling. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Human ortholog(s) of this gene implicated in renal hypomagnesemia 7, with or without dilated cardiomyopathy. Orthologous to human RRAGD (Ras related GTP binding D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 27.7), cortex adult (RPKM 13.1) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rragd in Genome Data Viewer
    Location:
    4 A5; 4 14.57 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32982998..33022180)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32982998..33022180)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 6 Neighboring gene STARR-seq mESC enhancer starr_09871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32993701-32993916 Neighboring gene enoyl-CoA hydratase domain-containing protein 2, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_09876 Neighboring gene STARR-seq mESC enhancer starr_09877 Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069120-33069321 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:33069732-33069841 Neighboring gene STARR-seq mESC enhancer starr_09878 Neighboring gene STARR-seq mESC enhancer starr_09880 Neighboring gene RIKEN cDNA 4933421O10 gene Neighboring gene ubiquitin-conjugating enzyme E2J 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity. Zhang Y, et al. J Immunother Cancer, 2021 Apr. PMID 33883257, Free PMC Article
    2. Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size. Srivastava AK, et al. J Bone Miner Res, 2005 Jun. PMID 15883645
    3. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato M, et al. Mech Dev, 2004 Jun. PMID 15172686
    4. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
    5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity.
      Title: Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to leucine starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ras-related GTP-binding protein D
    Names
    rag D
    ragD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369055.1 → NP_001355984.1  ras-related GTP-binding protein D isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL772288
      Consensus CDS
      CCDS89724.1
      UniProtKB/Swiss-Prot
      Q6GTT2, Q7TT45, Q9CYC2
      UniProtKB/TrEMBL
      B1AWT3
      Related
      ENSMUSP00000029946.8, ENSMUST00000029946.14
      Conserved Domains (1) summary
      cd11385
      Location:118 → 292
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

    2. NM_027491.2 → NP_081767.2  ras-related GTP-binding protein D isoform 2

      See identical proteins and their annotated locations for NP_081767.2

      Status: VALIDATED

      Source sequence(s)
      AL772288, BC038137, CK387674
      Consensus CDS
      CCDS38704.1
      UniProtKB/Swiss-Prot
      Q6GTT2, Q7TT45, Q9CYC2
      UniProtKB/TrEMBL
      B1AWT2
      Related
      ENSMUSP00000095792.4, ENSMUST00000098190.10
      Conserved Domains (2) summary
      cd11385
      Location:63 → 237
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D
      COG1100
      Location:63 → 237
      Gem1; GTPase SAR1 family domain [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      32982998..33022180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TT45.2 GenPept UniProtKB/Swiss-Prot:Q7TT45

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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