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    PRC1 protein regulator of cytokinesis 1 [ Homo sapiens (human) ]

    Gene ID: 9055, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PRC1provided by HGNC
    Official Full Name
    protein regulator of cytokinesis 1provided by HGNC
    Primary source
    HGNC:HGNC:9341
    See related
    Ensembl:ENSG00000198901 MIM:603484; AllianceGenome:HGNC:9341
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASE1; MAP65
    Summary
    This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
    Expression
    Broad expression in bone marrow (RPKM 31.0), testis (RPKM 24.4) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRC1 in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90966040..90994535, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88725621..88754118, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91509270..91537765, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:91496471-91496971 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:91497796-91498350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6834 Neighboring gene RCCD1 and UNC45A antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6836 Neighboring gene RCC1 domain containing 1 Neighboring gene PRC1 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:91526592-91527791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:91537071-91537938 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:91537939-91538805 Neighboring gene uncharacterized LOC124903556 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:91547812-91547974 Neighboring gene VPS33B late endosome and lysosome associated Neighboring gene uncharacterized LOC105370970

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2. Yun HJ, et al. Exp Mol Med, 2008 Jun 30. PMID 18587273, Free PMC Article
    2. DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression. Guo R, et al. Nat Microbiol, 2020 Aug. PMID 32424339, Free PMC Article
    3. PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway. Zhan P, et al. Mol Cancer, 2017 Jun 24. PMID 28646916, Free PMC Article
    4. Near-atomic cryo-EM structure of PRC1 bound to the microtubule. Kellogg EH, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27493215, Free PMC Article
    5. Mitotic phosphorylation of PRC1 at Thr470 is required for PRC1 oligomerization and proper central spindle organization. Fu C, et al. Cell Res, 2007 May. PMID 17438553

    See all (164) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1.
      Title: Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1.
    2. Protein regulator of cytokinesis 1: a potential oncogenic driver.
      Title: Protein regulator of cytokinesis 1: a potential oncogenic driver.
    3. Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis.
      Title: Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis.
    4. Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
      Title: Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.
    5. CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.
      Title: CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.
    6. Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus.
      Title: Expression of the cytokinesis regulator PRC1 results in p53-pathway activation in A549 cells but does not directly regulate gene expression in the nucleus.
    7. PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib.
      Title: PRC1 plays an important role in lung adenocarcinoma and is potentially targeted by fostamatinib.
    8. Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma.
      Title: Protein Regulator of Cytokinesis 1 (PRC1) Upregulation Promotes Immune Suppression in Liver Hepatocellular Carcinoma.
    9. Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption.
      Title: Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption.
    10. Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces.
      Title: Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces.
    Submit: New GeneRIF Correction See all GeneRIFs (73)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC1671, MGC3669

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle elongation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle microtubule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein regulator of cytokinesis 1
    Names
    anaphase spindle elongation 1 homolog
    protein regulating cytokinesis 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050647.2 RefSeqGene

      Range
      5000..33495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267580.2 → NP_001254509.2  protein regulator of cytokinesis 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses and alternate splice site and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC068831
      Consensus CDS
      CCDS45353.2
      Related
      ENSP00000409549.2, ENST00000442656.6
      Conserved Domains (1) summary
      pfam03999
      Location:22 → 508
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    2. NM_003981.4 → NP_003972.2  protein regulator of cytokinesis 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC068831
      Consensus CDS
      CCDS32334.1
      UniProtKB/Swiss-Prot
      A6NC44, B4DLR1, H9KV59, O43663, Q9BSB6
      Related
      ENSP00000377793.3, ENST00000394249.8
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 615
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    3. NM_199413.3 → NP_955445.2  protein regulator of cytokinesis 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC068831
      Consensus CDS
      CCDS45352.1
      Related
      ENSP00000354679.5, ENST00000361188.9
      Conserved Domains (1) summary
      COG1196
      Location:96 → 414
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      90966040..90994535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022714.3 → XP_016878203.1  protein regulator of cytokinesis 1 isoform X7

    2. XM_047433314.1 → XP_047289270.1  protein regulator of cytokinesis 1 isoform X29

    3. XM_047433310.1 → XP_047289266.1  protein regulator of cytokinesis 1 isoform X26

    4. XM_011522192.3 → XP_011520494.1  protein regulator of cytokinesis 1 isoform X20

      Conserved Domains (4) summary
      pfam03999
      Location:37 → 494
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:306 → 444
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      pfam13094
      Location:35 → 180
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      cl00711
      Location:141 → 304
      Glyco_hydro_77; 4-alpha-glucanotransferase

    5. XM_047433313.1 → XP_047289269.1  protein regulator of cytokinesis 1 isoform X28

    6. XM_047433311.1 → XP_047289267.1  protein regulator of cytokinesis 1 isoform X27

    7. XM_047433305.1 → XP_047289261.1  protein regulator of cytokinesis 1 isoform X21

    8. XM_047433306.1 → XP_047289262.1  protein regulator of cytokinesis 1 isoform X22

    9. XM_047433300.1 → XP_047289256.1  protein regulator of cytokinesis 1 isoform X16

    10. XM_047433301.1 → XP_047289257.1  protein regulator of cytokinesis 1 isoform X17

    11. XM_047433309.1 → XP_047289265.1  protein regulator of cytokinesis 1 isoform X25

    12. XM_047433307.1 → XP_047289263.1  protein regulator of cytokinesis 1 isoform X23

    13. XM_047433298.1 → XP_047289254.1  protein regulator of cytokinesis 1 isoform X13

    14. XM_017022716.3 → XP_016878205.1  protein regulator of cytokinesis 1 isoform X14

    15. XM_011522190.4 → XP_011520492.1  protein regulator of cytokinesis 1 isoform X9

      Conserved Domains (4) summary
      pfam03999
      Location:37 → 544
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:356 → 494
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      pfam13094
      Location:35 → 194
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      cl00711
      Location:203 → 354
      Glyco_hydro_77; 4-alpha-glucanotransferase

    16. XM_047433297.1 → XP_047289253.1  protein regulator of cytokinesis 1 isoform X11

    17. XM_047433304.1 → XP_047289260.1  protein regulator of cytokinesis 1 isoform X19

    18. XM_047433299.1 → XP_047289255.1  protein regulator of cytokinesis 1 isoform X15

    19. XM_047433295.1 → XP_047289251.1  protein regulator of cytokinesis 1 isoform X5

    20. XM_017022713.3 → XP_016878202.1  protein regulator of cytokinesis 1 isoform X6

    21. XM_011522189.3 → XP_011520491.1  protein regulator of cytokinesis 1 isoform X3

      Conserved Domains (2) summary
      pfam03999
      Location:37 → 564
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      cl00711
      Location:260 → 411
      Glyco_hydro_77; 4-alpha-glucanotransferase

    22. XM_017022712.3 → XP_016878201.1  protein regulator of cytokinesis 1 isoform X4

    23. XM_006720760.3 → XP_006720823.1  protein regulator of cytokinesis 1 isoform X12

      Conserved Domains (3) summary
      pfam03999
      Location:37 → 562
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413 → 562
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260 → 411
      Glyco_hydro_77; 4-alpha-glucanotransferase

    24. XM_005254987.4 → XP_005255044.1  protein regulator of cytokinesis 1 isoform X8

      Conserved Domains (3) summary
      pfam03999
      Location:37 → 560
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413 → 551
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260 → 411
      Glyco_hydro_77; 4-alpha-glucanotransferase

    25. XM_006720759.3 → XP_006720822.1  protein regulator of cytokinesis 1 isoform X10

      See identical proteins and their annotated locations for XP_006720822.1

      Conserved Domains (3) summary
      pfam03999
      Location:37 → 549
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413 → 560
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260 → 411
      Glyco_hydro_77; 4-alpha-glucanotransferase

    26. XM_011522188.4 → XP_011520490.1  protein regulator of cytokinesis 1 isoform X2

      Conserved Domains (3) summary
      pfam03999
      Location:37 → 583
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413 → 551
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260 → 411
      Glyco_hydro_77; 4-alpha-glucanotransferase

    27. XM_011522187.3 → XP_011520489.1  protein regulator of cytokinesis 1 isoform X1

      Conserved Domains (3) summary
      pfam03999
      Location:37 → 601
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413 → 551
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260 → 411
      Glyco_hydro_77; 4-alpha-glucanotransferase

    28. XM_047433308.1 → XP_047289264.1  protein regulator of cytokinesis 1 isoform X24

    29. XM_047433303.1 → XP_047289259.1  protein regulator of cytokinesis 1 isoform X18

    30. XM_011522191.4 → XP_011520493.1  protein regulator of cytokinesis 1 isoform X10

      See identical proteins and their annotated locations for XP_011520493.1

      Conserved Domains (3) summary
      pfam03999
      Location:37 → 549
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam08418
      Location:413 → 560
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
      cl00711
      Location:260 → 411
      Glyco_hydro_77; 4-alpha-glucanotransferase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      88725621..88754118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379147.1 → XP_054235122.1  protein regulator of cytokinesis 1 isoform X7

    2. XM_054379170.1 → XP_054235145.1  protein regulator of cytokinesis 1 isoform X29

    3. XM_054379167.1 → XP_054235142.1  protein regulator of cytokinesis 1 isoform X26

    4. XM_054379161.1 → XP_054235136.1  protein regulator of cytokinesis 1 isoform X20

    5. XM_054379169.1 → XP_054235144.1  protein regulator of cytokinesis 1 isoform X28

    6. XM_054379168.1 → XP_054235143.1  protein regulator of cytokinesis 1 isoform X27

    7. XM_054379162.1 → XP_054235137.1  protein regulator of cytokinesis 1 isoform X21

    8. XM_054379163.1 → XP_054235138.1  protein regulator of cytokinesis 1 isoform X22

    9. XM_054379157.1 → XP_054235132.1  protein regulator of cytokinesis 1 isoform X16

    10. XM_054379158.1 → XP_054235133.1  protein regulator of cytokinesis 1 isoform X17

    11. XM_054379166.1 → XP_054235141.1  protein regulator of cytokinesis 1 isoform X25

    12. XM_054379164.1 → XP_054235139.1  protein regulator of cytokinesis 1 isoform X23

    13. XM_054379154.1 → XP_054235129.1  protein regulator of cytokinesis 1 isoform X13

    14. XM_054379155.1 → XP_054235130.1  protein regulator of cytokinesis 1 isoform X14

    15. XM_054379149.1 → XP_054235124.1  protein regulator of cytokinesis 1 isoform X9

    16. XM_054379151.1 → XP_054235126.1  protein regulator of cytokinesis 1 isoform X11

    17. XM_054379160.1 → XP_054235135.1  protein regulator of cytokinesis 1 isoform X19

    18. XM_054379156.1 → XP_054235131.1  protein regulator of cytokinesis 1 isoform X15

    19. XM_054379145.1 → XP_054235120.1  protein regulator of cytokinesis 1 isoform X5

    20. XM_054379146.1 → XP_054235121.1  protein regulator of cytokinesis 1 isoform X6

    21. XM_054379143.1 → XP_054235118.1  protein regulator of cytokinesis 1 isoform X3

    22. XM_054379144.1 → XP_054235119.1  protein regulator of cytokinesis 1 isoform X4

    23. XM_054379153.1 → XP_054235128.1  protein regulator of cytokinesis 1 isoform X12

    24. XM_054379148.1 → XP_054235123.1  protein regulator of cytokinesis 1 isoform X8

    25. XM_054379152.1 → XP_054235127.1  protein regulator of cytokinesis 1 isoform X10

    26. XM_054379142.1 → XP_054235117.1  protein regulator of cytokinesis 1 isoform X2

    27. XM_054379141.1 → XP_054235116.1  protein regulator of cytokinesis 1 isoform X1

    28. XM_054379165.1 → XP_054235140.1  protein regulator of cytokinesis 1 isoform X24

    29. XM_054379159.1 → XP_054235134.1  protein regulator of cytokinesis 1 isoform X18

    30. XM_054379150.1 → XP_054235125.1  protein regulator of cytokinesis 1 isoform X10

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199414.1: Suppressed sequence

      Description
      NM_199414.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43663.2 GenPept UniProtKB/Swiss-Prot:O43663

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