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    SNQ2 ATP-binding cassette transporter SNQ2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SNQ2
    Official Full Name
    ATP-binding cassette transporter SNQ2
    Primary source
    SGD:S000002418
    Locus tag
    YDR011W
    See related
    AllianceGenome:SGD:S000002418; FungiDB:YDR011W; VEuPathDB:YDR011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ABC-type xenobiotic transporter activity. Involved in intracellular monoatomic cation homeostasis. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SNQ2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (465919..470424)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene transcriptional regulator GAL3 Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L4B Neighboring gene DNA replication protein PSF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases. Servos J, et al. Mol Gen Genet, 1993 Jan. PMID 8437567
    2. Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs. van Leeuwen JS, et al. Toxicol In Vitro, 2012 Mar. PMID 22138569
    3. Characterization of the kinetics and mechanisms of inhibition of drugs interacting with the S. cerevisiae multidrug resistance pumps Pdr5p and Snq2p. Hendrych T, et al. Biochim Biophys Acta, 2009 Mar. PMID 19111673
    4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga K, et al. Biochem Biophys Res Commun, 2005 Mar 25. PMID 15707993
    5. Impact of the growth phase on the activity of multidrug resistance pumps and membrane potential of S. cerevisiae: effect of pump overproduction and carbon source. Cadek R, et al. Biochim Biophys Acta, 2004 Oct 11. PMID 15471577

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae.
      Title: Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae.
    2. Multidrug resistance transporters Snq2p and Pdr5p mediate caffeine efflux in Saccharomyces cerevisiae.Caffeine was exported by Snq2p and Pdr5p.
      Title: Multidrug resistance transporters Snq2p and Pdr5p mediate caffeine efflux in Saccharomyces cerevisiae.
    3. The multidrug resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers of biofilms.
      Title: Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies.
    4. Pdr5p and Snq2p transporters play important physiological roles and significantly influence the developmental phases and physiology of yeast populations growing in a liquid culture.
      Title: Putative role for ABC multidrug exporters in yeast quorum sensing.
    5. activity of Snq2 in a strain with wild-type PDR1 allele was shown to drop sharply on glucose depletion from the medium and then again at the end of the diauxic shift when the cells are adapted to growth on respiratory substrates.
      Title: Impact of the growth phase on the activity of multidrug resistance pumps and membrane potential of S. cerevisiae: effect of pump overproduction and carbon source.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ABC-type xenobiotic transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular monoatomic cation homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette transporter SNQ2
    NP_010294.1
    • Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      465919..470424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180319.1 → NP_010294.1  TPA: ATP-binding cassette transporter SNQ2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010294.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRZ7, P32568
      UniProtKB/TrEMBL
      C8Z4T0, N1P6B2
      Conserved Domains (1) summary
      TIGR00956
      Location:103 → 1480
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32568.2

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