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    SNZ3 pyridoxine biosynthesis protein SNZ3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SNZ3
    Official Full Name
    pyridoxine biosynthesis protein SNZ3
    Primary source
    SGD:S000001835
    Locus tag
    YFL059W
    See related
    AllianceGenome:SGD:S000001835; FungiDB:YFL059W; VEuPathDB:YFL059W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity. Involved in pyridoxine biosynthetic process and thiamine biosynthetic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SNZ3 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (11363..12259)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene cyanamide hydratase Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of an exceptionally conserved operon suggests enzymes for a new link between histidine and purine biosynthesis. Galperin MY, et al. Mol Microbiol, 1997 Apr. PMID 9159529
    2. Identification of novel metabolic engineering targets for S-adenosyl-L-methionine production in Saccharomyces cerevisiae via genome-scale engineering. Dong C, et al. Metab Eng, 2021 Jul. PMID 33713797
    3. A stationary-phase gene in Saccharomyces cerevisiae is a member of a novel, highly conserved gene family. Braun EL, et al. J Bacteriol, 1996 Dec. PMID 8955308, Free PMC Article
    4. Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Ito T, et al. Proc Natl Acad Sci U S A, 2000 Feb 1. PMID 10655498, Free PMC Article
    5. SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae. Paxhia MD, et al. G3 (Bethesda), 2019 Feb 7. PMID 30498136, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snz3p is a pyridoxal 5'-phosphate synthase required for thiamine biosynthesis.
      Title: SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amine-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in organic hydroxy compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridoxal phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxal phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridoxine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridoxine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thiamine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vitamin B6 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    pyridoxine biosynthesis protein SNZ3
    NP_116596.1
    • Pyridoxal-5'-phosphate synthase; involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamine in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO3; paralog of SNZ1 and SNZ2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      11363..12259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179908.1 → NP_116596.1  TPA: pyridoxine biosynthesis protein SNZ3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTH1, P43545
      UniProtKB/TrEMBL
      B3LPG5, B5VQ90, C8ZBV7
      Conserved Domains (1) summary
      TIGR00343
      Location:6 → 298
      TIGR00343; pyridoxal 5'-phosphate synthase, synthase subunit Pdx1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43545.1

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