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    GPG1 Gpg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPG1
    Official Full Name
    Gpg1p
    Primary source
    SGD:S000003089
    Locus tag
    YGL121C
    See related
    AllianceGenome:SGD:S000003089; FungiDB:YGL121C; VEuPathDB:YGL121C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in invasive growth in response to glucose limitation. Acts upstream of or within negative regulation of amyloid fibril formation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GPG1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (280777..281157, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S2 Neighboring gene mRNA-binding protein NAB2 Neighboring gene DEAH-box ATP-dependent RNA helicase PRP43 Neighboring gene protein kinase COQ8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A G-protein gamma subunit mimic is a general antagonist of prion propagation in Saccharomyces cerevisiae. Ishiwata M, et al. Proc Natl Acad Sci U S A, 2009 Jan 20. PMID 19129493, Free PMC Article
    2. Transcriptional profiling of Saccharomyces cerevisiae cells under adhesion-inducing conditions. Kleinschmidt M, et al. Mol Genet Genomics, 2005 Jun. PMID 15843968
    3. Disruption of six novel Saccharomyces cerevisiae genes reveals that YGL129c is necessary for growth in non-fermentable carbon sources, YGL128c for growth at low or high temperatures and YGL125w is implicated in the biosynthesis of methionine. Tizón B, et al. Yeast, 1999 Jan 30. PMID 10029993
    4. The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Harashima T, et al. Mol Cell, 2002 Jul. PMID 12150916
    5. Heterologous gln/asn-rich proteins impede the propagation of yeast prions by altering chaperone availability. Yang Z, et al. PLoS Genet, 2013. PMID 23358669, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of amyloid fibril formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gpg1p
    NP_011394.1
    • Proposed gamma subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      280777..281157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180986.1 → NP_011394.1  TPA: Gpg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU27, P53130
      UniProtKB/TrEMBL
      A6ZU61, B3LHI1, C7GM14, C8Z8D0, G2WDY1, N1P3G7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53130.1

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