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    Psd3 pleckstrin and Sec7 domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 234353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psd3provided by MGI
    Official Full Name
    pleckstrin and Sec7 domain containing 3provided by MGI
    Primary source
    MGI:MGI:1918215
    See related
    Ensembl:ENSMUSG00000030465 AllianceGenome:MGI:1918215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EFA6D; D430018P08; 4931420C21Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to act upstream of or within ARF protein signal transduction. Located in ruffle membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; eye; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human PSD3 (pleckstrin and Sec7 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 13.0), frontal lobe adult (RPKM 12.7) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Psd3 in Genome Data Viewer
    Location:
    8 B3.2- B3.3; 8 33.46 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (68141728..68664740, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (67689082..68212063, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21697 Neighboring gene STARR-seq mESC enhancer starr_21698 Neighboring gene predicted gene, 36247 Neighboring gene predicted gene, 44391 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:70237121-70237339 Neighboring gene predicted gene, 32888 Neighboring gene predicted gene, 53438 Neighboring gene predicted gene 15991 Neighboring gene STARR-seq mESC enhancer starr_21700 Neighboring gene predicted gene, 22018 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70681079-70681379 Neighboring gene STARR-seq mESC enhancer starr_21702 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70772052-70772353 Neighboring gene STARR-seq mESC enhancer starr_21703 Neighboring gene STARR-seq mESC enhancer starr_21704 Neighboring gene STARR-seq mESC enhancer starr_21705 Neighboring gene STARR-seq mESC enhancer starr_21706 Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene SH2 domain containing 4A Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 1 Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Distinct subcellular localization of alternative splicing variants of EFA6D, a guanine nucleotide exchange factor for Arf6, in the mouse brain. Fukaya M, et al. J Comp Neurol, 2016 Sep 1. PMID 27241101
    2. PSD3 downregulation confers protection against fatty liver disease. Mancina RM, et al. Nat Metab, 2022 Jan. PMID 35102341, Free PMC Article
    3. EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. Ueda T, et al. FEBS Lett, 2013 Jun 5. PMID 23603394
    4. Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain. Sakagami H, et al. Brain Res, 2006 Jun 6. PMID 16707115
    5. A crucial role for Arf6 in the response of commissural axons to Slit. Kinoshita-Kawada M, et al. Development, 2019 Feb 4. PMID 30674481, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PSD3 downregulation confers protection against fatty liver disease.
      Title: PSD3 downregulation confers protection against fatty liver disease.
    2. Genetic variants of EFA6D were found to be distributed in overlapping patterns throughout the subcellular brain.
      Title: Distinct subcellular localization of alternative splicing variants of EFA6D, a guanine nucleotide exchange factor for Arf6, in the mouse brain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6957

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ARF protein signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PH and SEC7 domain-containing protein 3
    Names
    exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D
    exchange factor for ARF6 D
    guanine nucleotide exchange factor for ADP ribosylation factor 6
    pleckstrin homology and SEC7 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419758.1 → NP_001406687.1  PH and SEC7 domain-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500, AC125262
      UniProtKB/Swiss-Prot
      Q2PFD7, Q3TTA1, Q80TN6, Q80UZ7, Q8CEA6
      UniProtKB/TrEMBL
      A0A1D5RLK2
      Related
      ENSMUSP00000148401.2, ENSMUST00000212505.2

    2. NM_001419759.1 → NP_001406688.1  PH and SEC7 domain-containing protein 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500, AC125262
      UniProtKB/TrEMBL
      F6Z9E6
      Related
      ENSMUSP00000041339.10, ENSMUST00000038959.16

    3. NM_001419760.1 → NP_001406689.1  PH and SEC7 domain-containing protein 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500

    4. NM_001419761.1 → NP_001406690.1  PH and SEC7 domain-containing protein 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500

    5. NM_001419762.1 → NP_001406691.1  PH and SEC7 domain-containing protein 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500

    6. NM_001419763.1 → NP_001406692.1  PH and SEC7 domain-containing protein 3 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500

    7. NM_027626.2 → NP_081902.1  PH and SEC7 domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500
      Consensus CDS
      CCDS52563.1
      UniProtKB/TrEMBL
      E9PUC5
      Related
      ENSMUSP00000112545.2, ENSMUST00000120071.8
      Conserved Domains (2) summary
      cd13295
      Location:109 → 234
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:114 → 222
      PH; PH domain

    8. NM_030263.6 → NP_084539.2  PH and SEC7 domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_084539.2

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500
      Consensus CDS
      CCDS22340.1
      UniProtKB/Swiss-Prot
      Q2PFD7
      UniProtKB/TrEMBL
      Q78V97
      Related
      ENSMUSP00000091178.6, ENSMUST00000093468.12
      Conserved Domains (3) summary
      cd00171
      Location:52 → 206
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:251 → 376
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:256 → 364
      PH; PH domain

    9. NM_177698.6 → NP_808366.2  PH and SEC7 domain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_808366.2

      Status: VALIDATED

      Source sequence(s)
      AC109142, AC122500, AC125262
      Consensus CDS
      CCDS40355.3
      UniProtKB/TrEMBL
      F6Z9E6
      Related
      ENSMUSP00000091179.5, ENSMUST00000093469.11
      Conserved Domains (3) summary
      cd00171
      Location:537 → 692
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:737 → 862
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:742 → 850
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      68141728..68664740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153921.1 → XP_036009814.1  PH and SEC7 domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A1D5RMH7
      Related
      ENSMUSP00000148783.2, ENSMUST00000212960.2
      Conserved Domains (2) summary
      cd00171
      Location:823 → 977
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1022 → 1147
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    2. XM_036153919.1 → XP_036009812.1  PH and SEC7 domain-containing protein 3 isoform X1

      Conserved Domains (2) summary
      cd00171
      Location:823 → 977
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1022 → 1147
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    3. XM_036153918.1 → XP_036009811.1  PH and SEC7 domain-containing protein 3 isoform X1

      Conserved Domains (2) summary
      cd00171
      Location:823 → 977
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1022 → 1147
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    4. XM_036153920.1 → XP_036009813.1  PH and SEC7 domain-containing protein 3 isoform X2

      Conserved Domains (2) summary
      cd00171
      Location:822 → 976
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1021 → 1146
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    5. XM_036153917.1 → XP_036009810.1  PH and SEC7 domain-containing protein 3 isoform X1

      Conserved Domains (2) summary
      cd00171
      Location:823 → 977
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:1022 → 1147
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    6. XM_036153923.1 → XP_036009816.1  PH and SEC7 domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A1D5RLK2
      Conserved Domains (2) summary
      cd00171
      Location:569 → 723
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:768 → 893
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    7. XM_036153922.1 → XP_036009815.1  PH and SEC7 domain-containing protein 3 isoform X4

      UniProtKB/Swiss-Prot
      Q2PFD7, Q3TTA1, Q80TN6, Q80UZ7, Q8CEA6
      Conserved Domains (2) summary
      cd00171
      Location:570 → 724
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:769 → 894
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    8. XM_036153927.1 → XP_036009820.1  PH and SEC7 domain-containing protein 3 isoform X10

      UniProtKB/TrEMBL
      F6Z9E6
      Conserved Domains (2) summary
      cd00171
      Location:505 → 659
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:704 → 829
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    9. XM_036153925.1 → XP_036009818.1  PH and SEC7 domain-containing protein 3 isoform X8

      UniProtKB/TrEMBL
      F6Z9E6
      Conserved Domains (2) summary
      cd00171
      Location:536 → 690
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:735 → 860
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    10. XM_036153924.1 → XP_036009817.1  PH and SEC7 domain-containing protein 3 isoform X7

      UniProtKB/TrEMBL
      F6Z9E6
      Conserved Domains (2) summary
      cd00171
      Location:537 → 691
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:736 → 861
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    11. XM_036153928.1 → XP_036009821.1  PH and SEC7 domain-containing protein 3 isoform X10

      UniProtKB/TrEMBL
      F6Z9E6
      Conserved Domains (2) summary
      cd00171
      Location:505 → 659
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:704 → 829
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    12. XM_036153931.1 → XP_036009824.1  PH and SEC7 domain-containing protein 3 isoform X21

      Conserved Domains (2) summary
      cd00171
      Location:52 → 206
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:251 → 376
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

    13. XM_017312704.3 → XP_017168193.1  PH and SEC7 domain-containing protein 3 isoform X9

      Conserved Domains (1) summary
      cd00171
      Location:823 → 967
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    14. XM_017312705.3 → XP_017168194.1  PH and SEC7 domain-containing protein 3 isoform X11

      Conserved Domains (1) summary
      cd00171
      Location:823 → 966
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    15. XM_036153929.1 → XP_036009822.1  PH and SEC7 domain-containing protein 3 isoform X12

      Conserved Domains (1) summary
      cd00171
      Location:823 → 968
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    16. XM_017312707.3 → XP_017168196.1  PH and SEC7 domain-containing protein 3 isoform X18

      Conserved Domains (2) summary
      COG5307
      Location:701 → 879
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      cl00136
      Location:823 → 879
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    17. XM_011242288.4 → XP_011240590.1  PH and SEC7 domain-containing protein 3 isoform X13

      Conserved Domains (2) summary
      COG5307
      Location:701 → 934
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      cd00171
      Location:823 → 936
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    18. XM_036153930.1 → XP_036009823.1  PH and SEC7 domain-containing protein 3 isoform X19

      Conserved Domains (2) summary
      COG5307
      Location:701 → 879
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      cl00136
      Location:823 → 879
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    19. XM_006509619.5 → XP_006509682.1  PH and SEC7 domain-containing protein 3 isoform X14

      Conserved Domains (2) summary
      COG5307
      Location:701 → 934
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      cd00171
      Location:823 → 936
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    20. XM_017312706.3 → XP_017168195.1  PH and SEC7 domain-containing protein 3 isoform X17

      Conserved Domains (2) summary
      COG5307
      Location:701 → 879
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      cl00136
      Location:823 → 879
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    21. XM_006509620.5 → XP_006509683.1  PH and SEC7 domain-containing protein 3 isoform X15

      Conserved Domains (2) summary
      COG5307
      Location:701 → 934
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      cd00171
      Location:823 → 936
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    22. XM_017312709.3 → XP_017168198.1  PH and SEC7 domain-containing protein 3 isoform X20

      Conserved Domains (2) summary
      COG5307
      Location:701 → 879
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      cl00136
      Location:823 → 879
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    23. XM_006509621.5 → XP_006509684.1  PH and SEC7 domain-containing protein 3 isoform X16

      Conserved Domains (2) summary
      COG5307
      Location:701 → 934
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
      cd00171
      Location:823 → 938
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

    RNA

    1. XR_003947255.2 RNA Sequence

    2. XR_003947256.1 RNA Sequence

    3. XR_003947257.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2PFD7.2 GenPept UniProtKB/Swiss-Prot:Q2PFD7

    Gene LinkOut

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