Oxct2b 3-oxoacid CoA transferase 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oxct2bprovided by MGI
Official Full Name: 3-oxoacid CoA transferase 2Bprovided by MGI
Primary source: MGI:MGI:2664115
See related: Ensembl:ENSMUSG00000076438 AllianceGenome:MGI:2664115
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Scot-t2
Summary: Predicted to enable succinyl-CoA:3-oxo-acid CoA-transferase activity. Predicted to be involved in cellular ketone body metabolic process. Predicted to act upstream of or within generation of precursor metabolites and energy. Located in mitochondrion. Is expressed in appendicular skeleton; cranium; integumental system; and skin. Orthologous to human OXCT2 (3-oxoacid CoA-transferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.38 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (123010041..123011793)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (123116248..123118000)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oxct2a and Oxct2b are testicular haploid germ cell-specific genes
Title: Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinyl-CoA:3-oxo-acid CoA-transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within generation of precursor metabolites and energy	TAS Traceable Author Statement more info	PubMed
involved_in ketone body catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ketone body metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISA Inferred from Sequence Alignment more info	PubMed
located_in motile cilium	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial

Names: succinyl CoA:3-oxoacid CoA-transferase; testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2

NP_862907.2

EC 2.8.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181859.3 → NP_862907.2 succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial precursor

See identical proteins and their annotated locations for NP_862907.2

Status: VALIDATED

Source sequence(s)

AB049996, BC113758, CJ047771

Consensus CDS

CCDS18609.1

UniProtKB/Swiss-Prot

Q2HJ06, Q9ESL0

UniProtKB/TrEMBL

A0A0R4J198

Related

ENSMUSP00000099708.5, ENSMUST00000102648.6

Conserved Domains (2) summary

COG1788
Location:49 → 274

AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]

cl00339
Location:299 → 506

SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...